Chronic family stress interacts with 5-HTTLPR to predict prospective depressive symptoms among youth

Jessica L.Jenness Jenness, Benjamin L. Hankin, John R.Z. Abela, Jami F. Young, Andrew Smolen

Research output: Contribution to journalArticlepeer-review


Background: Previous research, predominantly with adults, has shown that the serotonin transporter gene (5-HTTLPR) interacts with stress (G × E) to predict depressive symptoms; however, few G × E studies have been conducted with youth using rigorous methods, particularly a prospective design and contextual interview to assess stress. This study examined the interaction between 5-HTTLPR and stress, both chronic and episodic, to predict longitudinal change in depressive symptoms among children and adolescents. Methods: A general community sample of youth (N = 200; 57% girls; mean age: 12.09 years old) was genotyped for 5-HTTLPR (rs 25531) at baseline. They were interviewed via contextual stress procedures to ascertain chronic family stress and episodic stressors and completed depressive symptoms questionnaires at baseline and 6 months later. Results: A significant G Ã - E showed that chronic family stress predicted prospective increases in depressive symptoms over 6 months among youth possessing the high-risk S allele. This G Ã - E was not found for episodic stressors occurring in the last 6 months. There was no moderation by sex or pubertal status. Conclusions: These findings advance knowledge on G Ã - E effects in depression among youth. This is the first study to show that chronic family stress, but not episodic stressors, when ascertained by rigorous stress interview, interacts with 5-HTTLPR to prospectively predict depressive symptoms among children and adolescents.

Original languageEnglish (US)
Pages (from-to)1074-1080
Number of pages7
JournalDepression and Anxiety
Issue number12
StatePublished - Dec 21 2011
Externally publishedYes


  • adolescents
  • children
  • depression
  • environment
  • genetics
  • serotonin

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health


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