Chronic dietary intake of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) at 5 or 25 parts per trillion in the monkey: TCDD kinetics and dose-effect estimate of reproductive toxicity

R. E. Bowman, S. L. Schantz, N. C.A. Weerasinghe, M. L. Gross, D. A. Barsotti

Research output: Contribution to journalArticlepeer-review

Abstract

TCDD half-life in seven adult female rhesus monkeys was 391 + 88 (S.E.) days. During four months of nursing, three mothers shed 22% of triglycerides and 21% of TCDD. Offspring accumulated in fat about 4.3 times the TCDD/fat of their mothers. A dose-effect estimate of reproductive toxicity is presented.

Original languageEnglish (US)
Pages (from-to)243-252
Number of pages10
JournalChemosphere
Volume18
Issue number1-6
DOIs
StatePublished - 1989
Externally publishedYes

ASJC Scopus subject areas

  • Environmental Engineering
  • Environmental Chemistry
  • Chemistry(all)
  • Pollution
  • Health, Toxicology and Mutagenesis

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