Chromosomal locations of the murine T-cell receptor alpha-chain gene and the T-cell gamma gene

David M Kranz, Haruo Saito, Christine M. Disteche, Karen Swisshelm, Dimitrina Pravtcheva, Frank H. Ruddle, Herman N. Eisen, Susumu Tonegawa

Research output: Contribution to journalArticle

Abstract

Two independent methods were used to identify the mouse chromosomes on which are located two families of immunoglobulin (Ig)-like genes that are rearranged and expressed in T lymphocytes. The genes coding for the a subunit of T-cell receptors are on chromosome 14 and the gamma genes, whose function is yet to be determined, are on chromosome 13. Since genes for the T-cell receptor β chain were previously shown to be on mouse chromosome 6, all three of the Ig-like multigene families expressed and rearranged in T cells are located on different chromosomes, just as are the B-cell multigene families for the Ig heavy chain, and the Ig kappa and lambda light chains. The findings do not support earlier contentions that genes for T-cell receptors are linked to the Ig heavy chain locus (mouse chromosome 12) or to the major histocompatibility complex (mouse chromosome 17).

Original languageEnglish (US)
Pages (from-to)941-945
Number of pages5
JournalScience
Volume227
Issue number4689
DOIs
StatePublished - Jan 1 1985
Externally publishedYes

Fingerprint

T-Cell Receptor alpha Genes
Immunoglobulin Heavy Chains
T-Lymphocytes
T-Cell Receptor Genes
Multigene Family
Genes
Chromosomes
Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 13
Chromosomes, Human, Pair 12
Immunoglobulin Genes
Chromosomes, Human, Pair 17
Chromosomes, Human, Pair 6
T-Cell Antigen Receptor
Major Histocompatibility Complex
Immunoglobulins
B-Lymphocytes
Light

ASJC Scopus subject areas

  • General

Cite this

Kranz, D. M., Saito, H., Disteche, C. M., Swisshelm, K., Pravtcheva, D., Ruddle, F. H., ... Tonegawa, S. (1985). Chromosomal locations of the murine T-cell receptor alpha-chain gene and the T-cell gamma gene. Science, 227(4689), 941-945. https://doi.org/10.1126/science.3918347

Chromosomal locations of the murine T-cell receptor alpha-chain gene and the T-cell gamma gene. / Kranz, David M; Saito, Haruo; Disteche, Christine M.; Swisshelm, Karen; Pravtcheva, Dimitrina; Ruddle, Frank H.; Eisen, Herman N.; Tonegawa, Susumu.

In: Science, Vol. 227, No. 4689, 01.01.1985, p. 941-945.

Research output: Contribution to journalArticle

Kranz, DM, Saito, H, Disteche, CM, Swisshelm, K, Pravtcheva, D, Ruddle, FH, Eisen, HN & Tonegawa, S 1985, 'Chromosomal locations of the murine T-cell receptor alpha-chain gene and the T-cell gamma gene', Science, vol. 227, no. 4689, pp. 941-945. https://doi.org/10.1126/science.3918347
Kranz DM, Saito H, Disteche CM, Swisshelm K, Pravtcheva D, Ruddle FH et al. Chromosomal locations of the murine T-cell receptor alpha-chain gene and the T-cell gamma gene. Science. 1985 Jan 1;227(4689):941-945. https://doi.org/10.1126/science.3918347
Kranz, David M ; Saito, Haruo ; Disteche, Christine M. ; Swisshelm, Karen ; Pravtcheva, Dimitrina ; Ruddle, Frank H. ; Eisen, Herman N. ; Tonegawa, Susumu. / Chromosomal locations of the murine T-cell receptor alpha-chain gene and the T-cell gamma gene. In: Science. 1985 ; Vol. 227, No. 4689. pp. 941-945.
@article{22b6c199c8294e97ac90e45eacd17703,
title = "Chromosomal locations of the murine T-cell receptor alpha-chain gene and the T-cell gamma gene",
abstract = "Two independent methods were used to identify the mouse chromosomes on which are located two families of immunoglobulin (Ig)-like genes that are rearranged and expressed in T lymphocytes. The genes coding for the a subunit of T-cell receptors are on chromosome 14 and the gamma genes, whose function is yet to be determined, are on chromosome 13. Since genes for the T-cell receptor β chain were previously shown to be on mouse chromosome 6, all three of the Ig-like multigene families expressed and rearranged in T cells are located on different chromosomes, just as are the B-cell multigene families for the Ig heavy chain, and the Ig kappa and lambda light chains. The findings do not support earlier contentions that genes for T-cell receptors are linked to the Ig heavy chain locus (mouse chromosome 12) or to the major histocompatibility complex (mouse chromosome 17).",
author = "Kranz, {David M} and Haruo Saito and Disteche, {Christine M.} and Karen Swisshelm and Dimitrina Pravtcheva and Ruddle, {Frank H.} and Eisen, {Herman N.} and Susumu Tonegawa",
year = "1985",
month = "1",
day = "1",
doi = "10.1126/science.3918347",
language = "English (US)",
volume = "227",
pages = "941--945",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "4689",

}

TY - JOUR

T1 - Chromosomal locations of the murine T-cell receptor alpha-chain gene and the T-cell gamma gene

AU - Kranz, David M

AU - Saito, Haruo

AU - Disteche, Christine M.

AU - Swisshelm, Karen

AU - Pravtcheva, Dimitrina

AU - Ruddle, Frank H.

AU - Eisen, Herman N.

AU - Tonegawa, Susumu

PY - 1985/1/1

Y1 - 1985/1/1

N2 - Two independent methods were used to identify the mouse chromosomes on which are located two families of immunoglobulin (Ig)-like genes that are rearranged and expressed in T lymphocytes. The genes coding for the a subunit of T-cell receptors are on chromosome 14 and the gamma genes, whose function is yet to be determined, are on chromosome 13. Since genes for the T-cell receptor β chain were previously shown to be on mouse chromosome 6, all three of the Ig-like multigene families expressed and rearranged in T cells are located on different chromosomes, just as are the B-cell multigene families for the Ig heavy chain, and the Ig kappa and lambda light chains. The findings do not support earlier contentions that genes for T-cell receptors are linked to the Ig heavy chain locus (mouse chromosome 12) or to the major histocompatibility complex (mouse chromosome 17).

AB - Two independent methods were used to identify the mouse chromosomes on which are located two families of immunoglobulin (Ig)-like genes that are rearranged and expressed in T lymphocytes. The genes coding for the a subunit of T-cell receptors are on chromosome 14 and the gamma genes, whose function is yet to be determined, are on chromosome 13. Since genes for the T-cell receptor β chain were previously shown to be on mouse chromosome 6, all three of the Ig-like multigene families expressed and rearranged in T cells are located on different chromosomes, just as are the B-cell multigene families for the Ig heavy chain, and the Ig kappa and lambda light chains. The findings do not support earlier contentions that genes for T-cell receptors are linked to the Ig heavy chain locus (mouse chromosome 12) or to the major histocompatibility complex (mouse chromosome 17).

UR - http://www.scopus.com/inward/record.url?scp=0021940345&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021940345&partnerID=8YFLogxK

U2 - 10.1126/science.3918347

DO - 10.1126/science.3918347

M3 - Article

C2 - 3918347

AN - SCOPUS:0021940345

VL - 227

SP - 941

EP - 945

JO - Science

JF - Science

SN - 0036-8075

IS - 4689

ER -