Chromosomal locations of the murine T-cell receptor alpha-chain gene and the T-cell gamma gene

David M. Kranz, Haruo Saito, Christine M. Disteche, Karen Swisshelm, Dimitrina Pravtcheva, Frank H. Ruddle, Herman N. Eisen, Susumu Tonegawa

Research output: Contribution to journalArticle

Abstract

Two independent methods were used to identify the mouse chromosomes on which are located two families of immunoglobulin (Ig)-like genes that are rearranged and expressed in T lymphocytes. The genes coding for the a subunit of T-cell receptors are on chromosome 14 and the gamma genes, whose function is yet to be determined, are on chromosome 13. Since genes for the T-cell receptor β chain were previously shown to be on mouse chromosome 6, all three of the Ig-like multigene families expressed and rearranged in T cells are located on different chromosomes, just as are the B-cell multigene families for the Ig heavy chain, and the Ig kappa and lambda light chains. The findings do not support earlier contentions that genes for T-cell receptors are linked to the Ig heavy chain locus (mouse chromosome 12) or to the major histocompatibility complex (mouse chromosome 17).

Original languageEnglish (US)
Pages (from-to)941-945
Number of pages5
JournalScience
Volume227
Issue number4689
DOIs
StatePublished - 1985

ASJC Scopus subject areas

  • General

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    Kranz, D. M., Saito, H., Disteche, C. M., Swisshelm, K., Pravtcheva, D., Ruddle, F. H., Eisen, H. N., & Tonegawa, S. (1985). Chromosomal locations of the murine T-cell receptor alpha-chain gene and the T-cell gamma gene. Science, 227(4689), 941-945. https://doi.org/10.1126/science.3918347