Chromosomal amplification of the Escherichia coli lipB region confers high-level resistance to selenolipoic acid

Sean W. Jordan, John E. Cronan

Research output: Contribution to journalArticlepeer-review

Abstract

One of the mutants (slr7 mutant) of a wild-type Escherichia coli strain resistant to selenolipoic acid reported previously (K. E. Reed, T. W. Morris, and J. E. Cronan, Jr., Proc. Natl. Acad. Sci. USA 91:3720-3724, 1994) unexpectedly grew on minimal medium following transductional introduction of a lipA null mutation. We report that the slr7 strain carries a duplication of the lip chromosomal region that causes the phenotype of the mutant strain.

Original languageEnglish (US)
Pages (from-to)5495-5501
Number of pages7
JournalJournal of bacteriology
Volume184
Issue number19
DOIs
StatePublished - Oct 2002

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

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