Abstract
The choline transporter (ChT) is used to transporte choline-derivate- modified nanoparticles across the blood-brain barrier. It is demonstrated that ChT is an ideal Trojan horse. The choline-derivate-modified nanoparticles exhibit higher permeability across the brain capillary endothelial cells (BCECs) monolayer in vitro and higher gene distribution and expression in vivo.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4516-4520 |
| Number of pages | 5 |
| Journal | Advanced Materials |
| Volume | 23 |
| Issue number | 39 |
| DOIs | |
| State | Published - Oct 18 2011 |
| Externally published | Yes |
Keywords
- bis-quaternary ammonium compounds
- blood-brain barrier
- choline transporters
- gene delivery
- nanoparticles
ASJC Scopus subject areas
- General Materials Science
- Mechanics of Materials
- Mechanical Engineering
Fingerprint
Dive into the research topics of 'Choline-derivate-modified nanoparticles for brain-targeting gene delivery'. Together they form a unique fingerprint.Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS