TY - JOUR
T1 - Chlorinated Polyfluorinated Ether Sulfonates and Thyroid Hormone Levels in Adults
T2 - Isomers of C8 Health Project in China
AU - Li, Qing Qing
AU - Liu, Jiao Jiao
AU - Su, Fan
AU - Zhang, Yun Ting
AU - Wu, Lu Yin
AU - Chu, Chu
AU - Zhou, Yuanzhong
AU - Shen, Xubo
AU - Xiong, Shimin
AU - Geiger, Sarah Dee
AU - Qian, Zhengmin Min
AU - McMillin, Stephen Edward
AU - Dong, Guang Hui
AU - Zeng, Xiao Wen
N1 - Funding Information:
This study was funded by grants from the National Key Research and Development Program of China (Nos. 2018YFE0106900, 2018YFC1004300, 2018YFC1004302), the National Natural Science Foundation of China (No. 82073503), and the Natural Science Foundation of Guangdong Province (No. 2021B1515020015).
Publisher Copyright:
© 2021 American Chemical Society. All rights reserved.
PY - 2022/5/17
Y1 - 2022/5/17
N2 - Chlorinated polyfluorinated ether sulfonates (Cl-PFESAs) are one kind of replacement chemistry for perfluorooctanesulfonate (PFOS). Recent studies have shown that Cl-PFESAs could interfere with thyroid function in animal models. However, epidemiological evidence on the link between Cl-PFESAs and thyroid function remains scarce. In this study, we focused on two representative legacy perfluoroalkyl substances (PFAS), including PFOS and perfluorooctanoic acid (PFOA), and two PFOS alternatives (6:2 and 8:2 Cl-PFESAs) in the general adult population from a cross-sectional study, the “Isomers of C8 Health Project in China”. Three serum thyroid hormones (THs), thyroid stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4), were measured. We fitted generalized linear regression, restricted cubic spline regression, and Bayesian kernel machine regression models to assess associations of individual Cl-PFESAs, legacy PFAS, and PFAS mixtures with THs, respectively. We found individual PFAS and their mixtures were nonlinearly associated with THs. The estimated changes of the TSH level (μIU/mL) at the 95th percentile of 6:2 Cl-PFESA and PFOS against the 5th percentile were −0.74 (95% CI: −0.94, −0.54) and −1.18 (95% CI: −1.37, −0.98), respectively. The present study provided epidemiological evidence for the association of 6:2 Cl-PFESA with thyroid hormone levels in the general adult population.
AB - Chlorinated polyfluorinated ether sulfonates (Cl-PFESAs) are one kind of replacement chemistry for perfluorooctanesulfonate (PFOS). Recent studies have shown that Cl-PFESAs could interfere with thyroid function in animal models. However, epidemiological evidence on the link between Cl-PFESAs and thyroid function remains scarce. In this study, we focused on two representative legacy perfluoroalkyl substances (PFAS), including PFOS and perfluorooctanoic acid (PFOA), and two PFOS alternatives (6:2 and 8:2 Cl-PFESAs) in the general adult population from a cross-sectional study, the “Isomers of C8 Health Project in China”. Three serum thyroid hormones (THs), thyroid stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4), were measured. We fitted generalized linear regression, restricted cubic spline regression, and Bayesian kernel machine regression models to assess associations of individual Cl-PFESAs, legacy PFAS, and PFAS mixtures with THs, respectively. We found individual PFAS and their mixtures were nonlinearly associated with THs. The estimated changes of the TSH level (μIU/mL) at the 95th percentile of 6:2 Cl-PFESA and PFOS against the 5th percentile were −0.74 (95% CI: −0.94, −0.54) and −1.18 (95% CI: −1.37, −0.98), respectively. The present study provided epidemiological evidence for the association of 6:2 Cl-PFESA with thyroid hormone levels in the general adult population.
KW - Isomers of C8 Health Project
KW - chlorinated polyfluorinated ether sulfonates (Cl-PFESAs)
KW - perfluoroalkyl substances (PFAS)
KW - perfluorooctanesulfonate (PFOS)
KW - perfluorooctanoic acid (PFOA)
KW - thyroid hormones
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U2 - 10.1021/acs.est.1c03757
DO - 10.1021/acs.est.1c03757
M3 - Article
C2 - 35380809
AN - SCOPUS:85128483672
SN - 0013-936X
JO - Environmental Science and Technology
JF - Environmental Science and Technology
ER -