Cherenkov excited luminescence imaging induced by megavolt X-ray beams in the second near-infrared window

Xiangxi Meng; Yi Du; R. Wang; Ziyuan Li; S. Zhu; Hao Wu; Changhui Li; Weiqiang Chen; Shuming Nie; Qiushi Ren; Y. Lu

doi:10.1016/j.optcom.2019.05.017

Cherenkov excited luminescence imaging induced by megavolt X-ray beams in the second near-infrared window

Xiangxi Meng, Yi Du, R. Wang, Ziyuan Li, S. Zhu, Hao Wu, Changhui Li, Weiqiang Chen, Shuming Nie, Qiushi Ren, Y. Lu

Research output: Contribution to journal › Article › peer-review

Abstract

The Cherenkov radiation induced by megavolt X-ray beams of a medical linear accelerator is highly intense in blue and ultraviolet lights. This poses a challenge for in vivo imaging, which favors longer wavelengths. However, using quantum dots with a large Stokes shift, we converted the Cherenkov photons to fluorescent photons in the second near-infrared (NIR-II) window. A system was designed to provide shielding for the NIR-II camera, and high quality NIR-II CELI signal was acquired. The NIR-II CELI of X-ray beams was shown at various depths, and the condition to trigger it was also studied. Animal experiments showed this technique could visualize the delivery of X-ray radiation in mice qualitatively. We concluded that CELI induced by megavolt X-ray beams in the NIR-II window possesses a great potential as a quality control tool in radiotherapy.

Original language	English (US)
Pages (from-to)	417-421
Number of pages	5
Journal	Optics Communications
Volume	452
DOIs	https://doi.org/10.1016/j.optcom.2019.05.017
State	Published - Dec 1 2019

Keywords

Cherenkov radiation
Radiotherapy
Second near-infrared window
X-ray

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics
Physical and Theoretical Chemistry
Electrical and Electronic Engineering

Online availability

10.1016/j.optcom.2019.05.017

Library availability

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@article{2b8df529cc20424d9528624631638bbc,

title = "Cherenkov excited luminescence imaging induced by megavolt X-ray beams in the second near-infrared window",

abstract = "The Cherenkov radiation induced by megavolt X-ray beams of a medical linear accelerator is highly intense in blue and ultraviolet lights. This poses a challenge for in vivo imaging, which favors longer wavelengths. However, using quantum dots with a large Stokes shift, we converted the Cherenkov photons to fluorescent photons in the second near-infrared (NIR-II) window. A system was designed to provide shielding for the NIR-II camera, and high quality NIR-II CELI signal was acquired. The NIR-II CELI of X-ray beams was shown at various depths, and the condition to trigger it was also studied. Animal experiments showed this technique could visualize the delivery of X-ray radiation in mice qualitatively. We concluded that CELI induced by megavolt X-ray beams in the NIR-II window possesses a great potential as a quality control tool in radiotherapy.",

keywords = "Cherenkov radiation, Radiotherapy, Second near-infrared window, X-ray",

author = "Xiangxi Meng and Yi Du and R. Wang and Ziyuan Li and S. Zhu and Hao Wu and Changhui Li and Weiqiang Chen and Shuming Nie and Qiushi Ren and Y. Lu",

note = "Funding Information: This work is supported by the National Key Instrumentation Development Project of China (2013YQ030651), National Natural Science Foundation of China (NSFC) (81421004, 61571262, 11575095, 11505012), Natural Science Foundation of Beijing Municipality (No. 1184014, 1174016), China Postdoctoral Science Foundation (No. 2017M620542), and Capital's Funds for Health Improvement and Research (No. 2018-4-1027). Funding Information: This work is supported by the National Key Instrumentation Development Project of China ( 2013YQ030651 ), National Natural Science Foundation of China (NSFC) ( 81421004 , 61571262 , 11575095 , 11505012 ), Natural Science Foundation of Beijing Municipality (No. 1184014 , 1174016 ), China Postdoctoral Science Foundation (No. 2017M620542 ), and Capital{\textquoteright}s Funds for Health Improvement and Research (No. 2018-4-1027 ). Publisher Copyright: {\textcopyright} 2019",

year = "2019",

month = dec,

day = "1",

doi = "10.1016/j.optcom.2019.05.017",

language = "English (US)",

volume = "452",

pages = "417--421",

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T1 - Cherenkov excited luminescence imaging induced by megavolt X-ray beams in the second near-infrared window

AU - Meng, Xiangxi

AU - Du, Yi

AU - Wang, R.

AU - Li, Ziyuan

AU - Zhu, S.

AU - Wu, Hao

AU - Li, Changhui

AU - Chen, Weiqiang

AU - Nie, Shuming

AU - Ren, Qiushi

AU - Lu, Y.

N1 - Funding Information: This work is supported by the National Key Instrumentation Development Project of China (2013YQ030651), National Natural Science Foundation of China (NSFC) (81421004, 61571262, 11575095, 11505012), Natural Science Foundation of Beijing Municipality (No. 1184014, 1174016), China Postdoctoral Science Foundation (No. 2017M620542), and Capital's Funds for Health Improvement and Research (No. 2018-4-1027). Funding Information: This work is supported by the National Key Instrumentation Development Project of China ( 2013YQ030651 ), National Natural Science Foundation of China (NSFC) ( 81421004 , 61571262 , 11575095 , 11505012 ), Natural Science Foundation of Beijing Municipality (No. 1184014 , 1174016 ), China Postdoctoral Science Foundation (No. 2017M620542 ), and Capital’s Funds for Health Improvement and Research (No. 2018-4-1027 ). Publisher Copyright: © 2019

PY - 2019/12/1

Y1 - 2019/12/1

N2 - The Cherenkov radiation induced by megavolt X-ray beams of a medical linear accelerator is highly intense in blue and ultraviolet lights. This poses a challenge for in vivo imaging, which favors longer wavelengths. However, using quantum dots with a large Stokes shift, we converted the Cherenkov photons to fluorescent photons in the second near-infrared (NIR-II) window. A system was designed to provide shielding for the NIR-II camera, and high quality NIR-II CELI signal was acquired. The NIR-II CELI of X-ray beams was shown at various depths, and the condition to trigger it was also studied. Animal experiments showed this technique could visualize the delivery of X-ray radiation in mice qualitatively. We concluded that CELI induced by megavolt X-ray beams in the NIR-II window possesses a great potential as a quality control tool in radiotherapy.

AB - The Cherenkov radiation induced by megavolt X-ray beams of a medical linear accelerator is highly intense in blue and ultraviolet lights. This poses a challenge for in vivo imaging, which favors longer wavelengths. However, using quantum dots with a large Stokes shift, we converted the Cherenkov photons to fluorescent photons in the second near-infrared (NIR-II) window. A system was designed to provide shielding for the NIR-II camera, and high quality NIR-II CELI signal was acquired. The NIR-II CELI of X-ray beams was shown at various depths, and the condition to trigger it was also studied. Animal experiments showed this technique could visualize the delivery of X-ray radiation in mice qualitatively. We concluded that CELI induced by megavolt X-ray beams in the NIR-II window possesses a great potential as a quality control tool in radiotherapy.

KW - Cherenkov radiation

KW - Radiotherapy

KW - Second near-infrared window

KW - X-ray

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JF - Optics Communications

ER -

Cherenkov excited luminescence imaging induced by megavolt X-ray beams in the second near-infrared window

Abstract

Keywords

ASJC Scopus subject areas

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