Cherenkov excited luminescence imaging induced by megavolt X-ray beams in the second near-infrared window

Xiangxi Meng, Yi Du, R. Wang, Ziyuan Li, S. Zhu, Hao Wu, Changhui Li, Weiqiang Chen, Shuming Nie, Qiushi Ren, Y. Lu

Research output: Contribution to journalArticle

Abstract

The Cherenkov radiation induced by megavolt X-ray beams of a medical linear accelerator is highly intense in blue and ultraviolet lights. This poses a challenge for in vivo imaging, which favors longer wavelengths. However, using quantum dots with a large Stokes shift, we converted the Cherenkov photons to fluorescent photons in the second near-infrared (NIR-II) window. A system was designed to provide shielding for the NIR-II camera, and high quality NIR-II CELI signal was acquired. The NIR-II CELI of X-ray beams was shown at various depths, and the condition to trigger it was also studied. Animal experiments showed this technique could visualize the delivery of X-ray radiation in mice qualitatively. We concluded that CELI induced by megavolt X-ray beams in the NIR-II window possesses a great potential as a quality control tool in radiotherapy.

Original languageEnglish (US)
Pages (from-to)417-421
Number of pages5
JournalOptics Communications
Volume452
DOIs
StatePublished - Dec 1 2019

Fingerprint

infrared windows
Luminescence
luminescence
Infrared radiation
Imaging techniques
X rays
x rays
Photons
Radiation
Linear accelerators
Radiotherapy
photons
linear accelerators
radiation
quality control
ultraviolet radiation
Shielding
Semiconductor quantum dots
luminaires
Quality control

Keywords

  • Cherenkov radiation
  • Radiotherapy
  • Second near-infrared window
  • X-ray

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Physical and Theoretical Chemistry
  • Electrical and Electronic Engineering

Cite this

Cherenkov excited luminescence imaging induced by megavolt X-ray beams in the second near-infrared window. / Meng, Xiangxi; Du, Yi; Wang, R.; Li, Ziyuan; Zhu, S.; Wu, Hao; Li, Changhui; Chen, Weiqiang; Nie, Shuming; Ren, Qiushi; Lu, Y.

In: Optics Communications, Vol. 452, 01.12.2019, p. 417-421.

Research output: Contribution to journalArticle

Meng, Xiangxi ; Du, Yi ; Wang, R. ; Li, Ziyuan ; Zhu, S. ; Wu, Hao ; Li, Changhui ; Chen, Weiqiang ; Nie, Shuming ; Ren, Qiushi ; Lu, Y. / Cherenkov excited luminescence imaging induced by megavolt X-ray beams in the second near-infrared window. In: Optics Communications. 2019 ; Vol. 452. pp. 417-421.
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AU - Wu, Hao

AU - Li, Changhui

AU - Chen, Weiqiang

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