Cherenkov excited luminescence imaging induced by megavolt X-ray beams in the second near-infrared window

Xiangxi Meng, Yi Du, R. Wang, Ziyuan Li, S. Zhu, Hao Wu, Changhui Li, Weiqiang Chen, Shuming Nie, Qiushi Ren, Y. Lu

Research output: Contribution to journalArticle

Abstract

The Cherenkov radiation induced by megavolt X-ray beams of a medical linear accelerator is highly intense in blue and ultraviolet lights. This poses a challenge for in vivo imaging, which favors longer wavelengths. However, using quantum dots with a large Stokes shift, we converted the Cherenkov photons to fluorescent photons in the second near-infrared (NIR-II) window. A system was designed to provide shielding for the NIR-II camera, and high quality NIR-II CELI signal was acquired. The NIR-II CELI of X-ray beams was shown at various depths, and the condition to trigger it was also studied. Animal experiments showed this technique could visualize the delivery of X-ray radiation in mice qualitatively. We concluded that CELI induced by megavolt X-ray beams in the NIR-II window possesses a great potential as a quality control tool in radiotherapy.

Original languageEnglish (US)
Pages (from-to)417-421
Number of pages5
JournalOptics Communications
Volume452
DOIs
StatePublished - Dec 1 2019

Keywords

  • Cherenkov radiation
  • Radiotherapy
  • Second near-infrared window
  • X-ray

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Physical and Theoretical Chemistry
  • Electrical and Electronic Engineering

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