Chemoselective methylene hydroxylation in aromatic molecules

M Christina White; Jinpeng Zhao

Chemoselective methylene hydroxylation in aromatic molecules

M Christina White (Inventor), Jinpeng Zhao (Inventor)

Research output: Patent

Abstract

A chemoselective and reactive Mn(CF3-PDP) catalyst system that enables for the first time the strategic advantages of late-stage aliphatic C—H hydroxylation to be leveraged in aromatic compounds. This discovery will benefit small molecule therapeutics by enabling the rapid diversification of aromatic drugs and natural products and identification of their metabolites.

Original language	English (US)
U.S. patent number	10961266
Filing date	9/12/19
State	Published - Mar 30 2021

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title = "Chemoselective methylene hydroxylation in aromatic molecules",

abstract = "A chemoselective and reactive Mn(CF3-PDP) catalyst system that enables for the first time the strategic advantages of late-stage aliphatic C—H hydroxylation to be leveraged in aromatic compounds. This discovery will benefit small molecule therapeutics by enabling the rapid diversification of aromatic drugs and natural products and identification of their metabolites.",

author = "White, {M Christina} and Jinpeng Zhao",

note = "GOVERNMENT SUPPORT This invention was made with government support under Grant No. R35 GM122525 awarded by the National Institutes of Health. The government has certain rights in the invention. ; 10961266",

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T1 - Chemoselective methylene hydroxylation in aromatic molecules

AU - White, M Christina

AU - Zhao, Jinpeng

N1 - GOVERNMENT SUPPORT This invention was made with government support under Grant No. R35 GM122525 awarded by the National Institutes of Health. The government has certain rights in the invention.

PY - 2021/3/30

Y1 - 2021/3/30

N2 - A chemoselective and reactive Mn(CF3-PDP) catalyst system that enables for the first time the strategic advantages of late-stage aliphatic C—H hydroxylation to be leveraged in aromatic compounds. This discovery will benefit small molecule therapeutics by enabling the rapid diversification of aromatic drugs and natural products and identification of their metabolites.

AB - A chemoselective and reactive Mn(CF3-PDP) catalyst system that enables for the first time the strategic advantages of late-stage aliphatic C—H hydroxylation to be leveraged in aromatic compounds. This discovery will benefit small molecule therapeutics by enabling the rapid diversification of aromatic drugs and natural products and identification of their metabolites.

M3 - Patent

M1 - 10961266

Y2 - 2019/09/12

ER -

Chemoselective methylene hydroxylation in aromatic molecules

Abstract

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