Chemopreventive potential of wild lowbush fruits in multiple stages of carcinogenisis

Tristan F. Burns Kraft, Barbara M. Schmidt, G. G. Yousef, Christopher T.G. Knight, Muriel Cuendet, Young Hwa Kang, John M. Pezzuto, David S. Seigler, Mary Ann Lila

Research output: Contribution to journalArticlepeer-review

Abstract

Wild lowbush bluefoerry fruit extract was fractionated using vacuum chromatography and analyzed for chemopreventive potential using bioassays that test the ability of compounds to inhibit the initiation, promotion, and progression stages of carcinogenesis. A fraction containing phytosterols was active against the initiation stage (quinone reductase assay). However, more polar compounds were inhibitors of later stages of carcinogenesis; a fraction containing flavan-3-ols and fractions containing mainly anthocyanins, phenolic acids, flavan-3-ols, and some proanthocyanidin dimers demonstrated activity against the promotion stage (cyclooxygenase and ornithine decarboxylase assays, respectively), and a proanthocyanidin-rich fraction demonstrated antiproliferation activity (inhibition of cancerous marine hepatocyte proliferation is associated with the progression stage). These results indicate that lowbush blueberries contain a range of compounds that have bioactivity against multiple stages of carcinogenesis, and different types of phenolic compounds are active at different stages.

Original languageEnglish (US)
Pages (from-to)S159-S166
JournalJournal of food science
Volume70
Issue number3
DOIs
StatePublished - Apr 2005

Keywords

  • Anthocyanins
  • Cancer
  • Phenolics
  • Proanthocyanidins
  • Vaccinium angustifolium

ASJC Scopus subject areas

  • Food Science

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