Chemistry of Enoxysilacyclobutanes. 3. Uncatalyzed, Syn-Selective, Asymmetric Aldol Additions

Scott E Denmark, Brian D. Griedel

Research output: Contribution to journalArticlepeer-review

Abstract

Asymmetrically modified S,O-(alkoxysilacyclobutyl) ketene acetals derived from methanethiol esters reacted with aromatic aldehydes at low temperature to afford, after desilylation, the corresponding β-hydroxythiol ester aldolates in high enantiomeric excess (91–94% ee).

Original languageEnglish (US)
Pages (from-to)5136-5138
Number of pages3
JournalJournal of Organic Chemistry
Volume59
Issue number18
DOIs
StatePublished - Sep 1 1994

ASJC Scopus subject areas

  • Organic Chemistry

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