Abstract
The purpose of this study is to produce a platform device with the ability to detect a variety of pathogens based upon antigen-antibody interactions. The sensor comprises a nanoporous GeSe channel waveguide fabricated on a substrate, with an intermediate cladding buffer layer [GeSe2], which is required when the substrate does not transmit at the desired λ. The light from a laser source is then coupled through a fiber and prism into the waveguide and collected with the help of a lens into a detector. The top cladding layer is a Ge28Sb12Se60 thin film in which biomolecules can be 'tethered' via functionalization of the surface. Therefore the surface chemistry of the thin film and the specificity of antibody to its antigen are important considerations. This paper will focus primarily on the surface characterization of the top cladding layer using XPS, AFM, ellipsometry, contact angle measurements and diffuse reflectance analysis.
Original language | English (US) |
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Article number | 34 |
Pages (from-to) | 231-238 |
Number of pages | 8 |
Journal | Proceedings of SPIE - The International Society for Optical Engineering |
Volume | 5591 |
DOIs | |
State | Published - 2004 |
Externally published | Yes |
Event | Lab-on-a-Chip: Platforms, Devices, and Applications - Philadelphia, PA, United States Duration: Oct 26 2004 → Oct 28 2004 |
Keywords
- Biosensor
- E.coli
- Optical sensor
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Condensed Matter Physics
- Computer Science Applications
- Applied Mathematics
- Electrical and Electronic Engineering