Characterization of the protective response against a homologous challenge infection with Strongyloides venezuelensis in rats

B. K. Baek, M. K. Islam, B. S. Kim, C. W. Lim, J. Hur, A. O. Oluoch, C. H. Kim, I. Kakoma

Research output: Contribution to journalArticlepeer-review

Abstract

The protective response in rats against a homologous challenge infection with Strongyloides venezuelensis was characterized. In an initial infection with 1000 filariform larvae and migrating larvae (L3) of S. venezuelensis, the population of L3 in the lungs on day 3 postinfection (PI), and that of adult worms in the small intestine on day 7 PI, were 180.8±14.5 and 336.8±70.7, respectively. The latter were gradually expelled towards day 42 PI. After the initial infection, the rats developed strong immunity against a homologous challenge infection as manifested by a marked reduction in worm populations, stunted body length and width, damage to reproductive organs, impaired egg production and rapid expulsion of the worms by day 14 after challenge. Expulsion of the worms was preceded by a significantly elevated (P<0.05) peripheral blood eosinophil (PBE) count, both in the initial (200.0±26.5×103ml) and the challenge infection (400.9±165.4×103ml). These findings suggest that rats acquire strong homologous immunity following initial exposure to S. venezuelensis. It is suggested that PBEs are involved in worm expulsion. A major target of these effector mechanisms is the reproductive system of S. venezuelensis.

Original languageEnglish (US)
Pages (from-to)217-227
Number of pages11
JournalVeterinary parasitology
Volume113
Issue number3-4
DOIs
StatePublished - May 1 2003

Keywords

  • Eosinophilia
  • Fecundity
  • Impaired egg production
  • Protective immunity
  • Strongyloides venezuelensis

ASJC Scopus subject areas

  • Parasitology
  • veterinary(all)

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