Characterization of potential endocrine-related health effects at low-dose levels of exposure to PCBs

Abraham Brouwer, Matthew P. Longnecker, Linda S. Birnbaum, Jim Cogliano, Paul Kostyniak, Jack Moore, Susan L Schantz, Gerhard Winneke

Research output: Contribution to journalReview article

Abstract

This article addresses issues related to the characterization of endocrine-related health effects resulting from low-level exposures to polychlorinated biphenyls (PCBs). It is not intended to be a comprehensive review of the literature but reflects workshop discussions. 'The Characterizing the Effects of Endocrine Disruptors on Human Health at Environmental Exposure Levels,' workshop provided a forum to discuss the methods and data needed to improve risk assessments of endocrine disrupters. This article contains an overview of endocrine-related (estrogen and thyroid system) interactions and other low-dose effects of PCBs. The data set on endocrine effects includes results obtained from mechanistic methods/ and models (receptor based, metabolism based, and transport protein based), as well as from in vivo models, including studies with experimental animals and wildlife species. Other low-dose effects induced by PCBs, such as neurodevelopmental and reproductive effects and endocrine-sensitive tumors, have been evaluated with respect to a possible causative linkage with PCB-induced alterations in endocrine systems. In addition, studies of low-dose exposure and effects in human populations are presented and critically evaluated. A list of conclusions and recommendations is included.

Original languageEnglish (US)
Pages (from-to)639-649
Number of pages11
JournalEnvironmental health perspectives
Volume107
Issue numberSUPPL. 4
StatePublished - Jan 1 1999

Fingerprint

Polychlorinated Biphenyls
PCB
Health
Endocrine disrupters
endocrine disruptor
Education
Endocrine Disruptors
Endocrine System
Environmental Exposure
Metabolism
Risk assessment
Tumors
Carrier Proteins
Thyroid Gland
Estrogens
Animals
endocrine system
dose
effect
exposure

Keywords

  • Endocrine
  • Estrogen
  • Health
  • Human
  • Low dose
  • PCBs
  • Risk
  • Thyroid

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

Brouwer, A., Longnecker, M. P., Birnbaum, L. S., Cogliano, J., Kostyniak, P., Moore, J., ... Winneke, G. (1999). Characterization of potential endocrine-related health effects at low-dose levels of exposure to PCBs. Environmental health perspectives, 107(SUPPL. 4), 639-649.

Characterization of potential endocrine-related health effects at low-dose levels of exposure to PCBs. / Brouwer, Abraham; Longnecker, Matthew P.; Birnbaum, Linda S.; Cogliano, Jim; Kostyniak, Paul; Moore, Jack; Schantz, Susan L; Winneke, Gerhard.

In: Environmental health perspectives, Vol. 107, No. SUPPL. 4, 01.01.1999, p. 639-649.

Research output: Contribution to journalReview article

Brouwer, A, Longnecker, MP, Birnbaum, LS, Cogliano, J, Kostyniak, P, Moore, J, Schantz, SL & Winneke, G 1999, 'Characterization of potential endocrine-related health effects at low-dose levels of exposure to PCBs', Environmental health perspectives, vol. 107, no. SUPPL. 4, pp. 639-649.
Brouwer A, Longnecker MP, Birnbaum LS, Cogliano J, Kostyniak P, Moore J et al. Characterization of potential endocrine-related health effects at low-dose levels of exposure to PCBs. Environmental health perspectives. 1999 Jan 1;107(SUPPL. 4):639-649.
Brouwer, Abraham ; Longnecker, Matthew P. ; Birnbaum, Linda S. ; Cogliano, Jim ; Kostyniak, Paul ; Moore, Jack ; Schantz, Susan L ; Winneke, Gerhard. / Characterization of potential endocrine-related health effects at low-dose levels of exposure to PCBs. In: Environmental health perspectives. 1999 ; Vol. 107, No. SUPPL. 4. pp. 639-649.
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