Abstract

The potential for using plasmon-resonant gold nanorods as targeted contrast agents for in vivo coherent optical imaging is investigated. Separation of the relative strengths of light scattering and absorption of plasmon-resonant nanorods are measured with a double-integrating sphere system at 774 and 1304nm. The maximum likelihood ratio is then used to test the statistical significance of optical changes observed after application of contrast agents to tissue phantoms. Gold plasmon-resonant nanorods with a longitudinal resonance near 800nm are imaged within varying concentrations of intralipid using a 101 dB sensitivity, 800nm optical coherence tomography (OCT) system. We estimate the minimum OCT detectible concentration of these nanorods (ca. 15×45nm) within 1.1% intralipid to be 25μg/mL of gold.

Original languageEnglish (US)
Article number08
Pages (from-to)50-60
Number of pages11
JournalProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume5703
DOIs
StatePublished - Aug 16 2005
EventPlasmonics in Biology and Medicine II - San Jose, CA, United States
Duration: Jan 24 2005Jan 25 2005

Keywords

  • Contrast agents
  • Integrating spheres
  • Nanorods
  • Optical coherence tomography
  • Plasmon resonance

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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