Characterization of plasmon-resonant gold nanorods as near-infrared optical contrast agents investigated using a double-integrating sphere system

Amy Oldenburg, Daniel A. Zweifel, Chenyang Xu, Alexander Wei, Stephen A. Boppart

Research output: Contribution to journalConference article

Abstract

The potential for using plasmon-resonant gold nanorods as targeted contrast agents for in vivo coherent optical imaging is investigated. Separation of the relative strengths of light scattering and absorption of plasmon-resonant nanorods are measured with a double-integrating sphere system at 774 and 1304nm. The maximum likelihood ratio is then used to test the statistical significance of optical changes observed after application of contrast agents to tissue phantoms. Gold plasmon-resonant nanorods with a longitudinal resonance near 800nm are imaged within varying concentrations of intralipid using a 101 dB sensitivity, 800nm optical coherence tomography (OCT) system. We estimate the minimum OCT detectible concentration of these nanorods (ca. 15×45nm) within 1.1% intralipid to be 25μg/mL of gold.

Original languageEnglish (US)
Article number08
Pages (from-to)50-60
Number of pages11
JournalProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume5703
DOIs
StatePublished - Aug 16 2005
EventPlasmonics in Biology and Medicine II - San Jose, CA, United States
Duration: Jan 24 2005Jan 25 2005

Fingerprint

Nanotubes
Nanorods
Gold
Contrast Media
nanorods
gold
Infrared radiation
Optical tomography
Optical Coherence Tomography
tomography
likelihood ratio
Optical Imaging
electromagnetic absorption
Light scattering
Light absorption
Maximum likelihood
light scattering
Tissue
Imaging techniques
Light

Keywords

  • Contrast agents
  • Integrating spheres
  • Nanorods
  • Optical coherence tomography
  • Plasmon resonance

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Cite this

Characterization of plasmon-resonant gold nanorods as near-infrared optical contrast agents investigated using a double-integrating sphere system. / Oldenburg, Amy; Zweifel, Daniel A.; Xu, Chenyang; Wei, Alexander; Boppart, Stephen A.

In: Progress in Biomedical Optics and Imaging - Proceedings of SPIE, Vol. 5703, 08, 16.08.2005, p. 50-60.

Research output: Contribution to journalConference article

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