Characterization of MYC-induced tumorigenesis by in situ lipid profiling

Richard H. Perry, David I. Bellovin, Emelyn H. Shroff, Ali I. Ismail, Tahera Zabuawala, Dean W. Felsher, Richard N. Zare

Research output: Contribution to journalArticlepeer-review


We apply desorption electrospray ionization mass spectrometry imaging (DESI-MSI) to provide an in situ lipidomic profile of genetically modified tissues from a conditional transgenic mouse model of MYC-induced hepatocellular carcinoma (HCC). This unique, label-free approach of combining DESI-MSI with the ability to turn specific genes on and off has led to the discovery of highly specific lipid molecules associated with MYC-induced tumor onset. We are able to distinguish normal from MYC-induced malignant cells. Our approach provides a strategy to define a precise molecular picture at a resolution of about 200 μm that may be useful in identifying lipid molecules that define how the MYC oncogene initiates and maintains tumorigenesis.

Original languageEnglish (US)
Pages (from-to)4259-4262
Number of pages4
JournalAnalytical Chemistry
Issue number9
StatePublished - May 7 2013

ASJC Scopus subject areas

  • Analytical Chemistry


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