Characterization of chlorovinylcobalamin, a putative intermediate in reductive degradation of chlorinated ethylenes

Kevin M. McCauley, Scott R. Wilson, Wilfred A. Van der Donk

Research output: Contribution to journalArticlepeer-review

Abstract

The first X-ray structure of a vinylcobalamin is reported. Chlorovinylcobalamin is formed in the reaction of cob(I)alamin with chloroacetylene. Subsequently, cob(I)alamin catalyzes the reduction of chlorovinylcobalamin to vinylcobalamin in the presence of excess titanium(III)citrate. Introduction of a chlorine onto the vinyl group of vinylcobalamin greatly changes its reduction potential. These results are discussed with respect to vitamin B12-catalyzed dechlorination of perchloroethylene, a pollutant on the priority list of the EPA.

Original languageEnglish (US)
Pages (from-to)4410-4411
Number of pages2
JournalJournal of the American Chemical Society
Volume125
Issue number15
DOIs
StatePublished - Apr 16 2003

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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