Characterization of a protein that appears in the nervous system of the moth Manduca sexta coincident with neuronal death

Michelle E. Montemayor, Susan E. Fahrbach, Carol S. Giometti, Edward J. Roy

Research output: Contribution to journalArticle


Two-dimensional gel electrophoresis was used to locate potential neuronal death-related proteins in the moth Manduca sexta. Protein patterns of ganglia of pharate adult moths (taken prior to adult ecdysis) compared with protein patterns of one-day-old adults revealed reproducible changes in protein patterns. An acidic protein of approximately 40000 Da was present in all samples from adult moths undergoing neuronal death and essentially absent from pharate adult samples.

Original languageEnglish (US)
Pages (from-to)219-222
Number of pages4
JournalFEBS Letters
Issue number1-2
StatePublished - Dec 10 1990



  • Abdominal ganglia
  • Cell death
  • Gel electrophoresis, 2-D
  • Manduca sexta
  • Metamorphosis
  • Neuronal death
  • Protein synthesis

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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