Abstract
The use of biological field effect transistors (BioFETs) for the detection of biochemical events will yield new sensing systems that are smaller, less expensive, faster, and capable of multiplexing. Here, we present a novel massively parallel dual-gated BioFET (DG-BioFET) platform with over a million transistors in a 7 × 7 mm2 array that has all these benefits. Utilizing on-chip integrated circuits for row and column addressing and a PXI IC tester to measure signals, the drain current of each sensor in the 1024 × 1024 array is serially acquired in just 90 s. In this paper, we demonstrate that sensors in our massively parallel platform have standard transfer characteristics, high pH-sensitivity, and robust performance. In addition, we use the dual-gate operation and fast acquisition, unique in our platform, to improve the sensing performance of the system. We show that tailored biasing of the two DG-BioFET gates results in signal amplification above the Nernst limit (to 84 mV/pH) and redundancy techniques facilitate differential referencing, improving the resulting signal-to-noise ratio. Our platform encompasses the advantages of semiconductor-based biosensors, and demonstrates the benefits of high parallelism and FET dual-gate amplification for electrical and miniaturized biological sensing.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 100-110 |
| Number of pages | 11 |
| Journal | Sensors and Actuators, B: Chemical |
| Volume | 250 |
| DOIs | |
| State | Published - Jan 1 2017 |
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Keywords
- 1024 × 1024 array
- Beyond nernstian limit
- Biological field-effect transistor
- Dual-gate
- Multiplexed biosensing
- pH sensor
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Instrumentation
- Condensed Matter Physics
- Surfaces, Coatings and Films
- Metals and Alloys
- Electrical and Electronic Engineering
- Materials Chemistry
Cite this
Characterization of a 1024 × 1024 DG-BioFET platform. / Duarte-Guevara, Carlos; Swaminathan, Vikhram; Reddy, Bobby; Wen, Chin Hua; Huang, Yu Jie; Huang, Jui Cheng; Liu, Yi Shao; Bashir, Rashid.
In: Sensors and Actuators, B: Chemical, Vol. 250, 01.01.2017, p. 100-110.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Characterization of a 1024 × 1024 DG-BioFET platform
AU - Duarte-Guevara, Carlos
AU - Swaminathan, Vikhram
AU - Reddy, Bobby
AU - Wen, Chin Hua
AU - Huang, Yu Jie
AU - Huang, Jui Cheng
AU - Liu, Yi Shao
AU - Bashir, Rashid
PY - 2017/1/1
Y1 - 2017/1/1
N2 - The use of biological field effect transistors (BioFETs) for the detection of biochemical events will yield new sensing systems that are smaller, less expensive, faster, and capable of multiplexing. Here, we present a novel massively parallel dual-gated BioFET (DG-BioFET) platform with over a million transistors in a 7 × 7 mm2 array that has all these benefits. Utilizing on-chip integrated circuits for row and column addressing and a PXI IC tester to measure signals, the drain current of each sensor in the 1024 × 1024 array is serially acquired in just 90 s. In this paper, we demonstrate that sensors in our massively parallel platform have standard transfer characteristics, high pH-sensitivity, and robust performance. In addition, we use the dual-gate operation and fast acquisition, unique in our platform, to improve the sensing performance of the system. We show that tailored biasing of the two DG-BioFET gates results in signal amplification above the Nernst limit (to 84 mV/pH) and redundancy techniques facilitate differential referencing, improving the resulting signal-to-noise ratio. Our platform encompasses the advantages of semiconductor-based biosensors, and demonstrates the benefits of high parallelism and FET dual-gate amplification for electrical and miniaturized biological sensing.
AB - The use of biological field effect transistors (BioFETs) for the detection of biochemical events will yield new sensing systems that are smaller, less expensive, faster, and capable of multiplexing. Here, we present a novel massively parallel dual-gated BioFET (DG-BioFET) platform with over a million transistors in a 7 × 7 mm2 array that has all these benefits. Utilizing on-chip integrated circuits for row and column addressing and a PXI IC tester to measure signals, the drain current of each sensor in the 1024 × 1024 array is serially acquired in just 90 s. In this paper, we demonstrate that sensors in our massively parallel platform have standard transfer characteristics, high pH-sensitivity, and robust performance. In addition, we use the dual-gate operation and fast acquisition, unique in our platform, to improve the sensing performance of the system. We show that tailored biasing of the two DG-BioFET gates results in signal amplification above the Nernst limit (to 84 mV/pH) and redundancy techniques facilitate differential referencing, improving the resulting signal-to-noise ratio. Our platform encompasses the advantages of semiconductor-based biosensors, and demonstrates the benefits of high parallelism and FET dual-gate amplification for electrical and miniaturized biological sensing.
KW - 1024 × 1024 array
KW - Beyond nernstian limit
KW - Biological field-effect transistor
KW - Dual-gate
KW - Multiplexed biosensing
KW - pH sensor
UR - http://www.scopus.com/inward/record.url?scp=85018975877&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85018975877&partnerID=8YFLogxK
U2 - 10.1016/j.snb.2017.04.107
DO - 10.1016/j.snb.2017.04.107
M3 - Article
AN - SCOPUS:85018975877
VL - 250
SP - 100
EP - 110
JO - Sensors and Actuators, B: Chemical
JF - Sensors and Actuators, B: Chemical
SN - 0925-4005
ER -