Abstract

The use of biological field effect transistors (BioFETs) for the detection of biochemical events will yield new sensing systems that are smaller, less expensive, faster, and capable of multiplexing. Here, we present a novel massively parallel dual-gated BioFET (DG-BioFET) platform with over a million transistors in a 7 × 7 mm2 array that has all these benefits. Utilizing on-chip integrated circuits for row and column addressing and a PXI IC tester to measure signals, the drain current of each sensor in the 1024 × 1024 array is serially acquired in just 90 s. In this paper, we demonstrate that sensors in our massively parallel platform have standard transfer characteristics, high pH-sensitivity, and robust performance. In addition, we use the dual-gate operation and fast acquisition, unique in our platform, to improve the sensing performance of the system. We show that tailored biasing of the two DG-BioFET gates results in signal amplification above the Nernst limit (to 84 mV/pH) and redundancy techniques facilitate differential referencing, improving the resulting signal-to-noise ratio. Our platform encompasses the advantages of semiconductor-based biosensors, and demonstrates the benefits of high parallelism and FET dual-gate amplification for electrical and miniaturized biological sensing.

Original languageEnglish (US)
Pages (from-to)100-110
Number of pages11
JournalSensors and Actuators, B: Chemical
Volume250
DOIs
StatePublished - Jan 1 2017

Fingerprint

Field effect transistors
platforms
Amplification
field effect transistors
Drain current
Sensors
Multiplexing
Biosensors
Redundancy
Integrated circuits
sensors
Signal to noise ratio
Transistors
redundancy
test equipment
multiplexing
bioinstrumentation
Semiconductor materials
integrated circuits
acquisition

Keywords

  • 1024 × 1024 array
  • Beyond nernstian limit
  • Biological field-effect transistor
  • Dual-gate
  • Multiplexed biosensing
  • pH sensor

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering
  • Materials Chemistry

Cite this

Duarte-Guevara, C., Swaminathan, V., Reddy, B., Wen, C. H., Huang, Y. J., Huang, J. C., ... Bashir, R. (2017). Characterization of a 1024 × 1024 DG-BioFET platform. Sensors and Actuators, B: Chemical, 250, 100-110. https://doi.org/10.1016/j.snb.2017.04.107

Characterization of a 1024 × 1024 DG-BioFET platform. / Duarte-Guevara, Carlos; Swaminathan, Vikhram; Reddy, Bobby; Wen, Chin Hua; Huang, Yu Jie; Huang, Jui Cheng; Liu, Yi Shao; Bashir, Rashid.

In: Sensors and Actuators, B: Chemical, Vol. 250, 01.01.2017, p. 100-110.

Research output: Contribution to journalArticle

Duarte-Guevara, C, Swaminathan, V, Reddy, B, Wen, CH, Huang, YJ, Huang, JC, Liu, YS & Bashir, R 2017, 'Characterization of a 1024 × 1024 DG-BioFET platform', Sensors and Actuators, B: Chemical, vol. 250, pp. 100-110. https://doi.org/10.1016/j.snb.2017.04.107
Duarte-Guevara C, Swaminathan V, Reddy B, Wen CH, Huang YJ, Huang JC et al. Characterization of a 1024 × 1024 DG-BioFET platform. Sensors and Actuators, B: Chemical. 2017 Jan 1;250:100-110. https://doi.org/10.1016/j.snb.2017.04.107
Duarte-Guevara, Carlos ; Swaminathan, Vikhram ; Reddy, Bobby ; Wen, Chin Hua ; Huang, Yu Jie ; Huang, Jui Cheng ; Liu, Yi Shao ; Bashir, Rashid. / Characterization of a 1024 × 1024 DG-BioFET platform. In: Sensors and Actuators, B: Chemical. 2017 ; Vol. 250. pp. 100-110.
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