Abstract
The Fe(ii) and α-ketoglutarate-dependent hydroxylase FrbJ was previously demonstrated to utilize FR-900098 synthesizing a second phosphonate FR-33289. Here we assessed its ability to hydroxylate other possible substrates, generating a library of potential antimalarial compounds. Through a series of bioassays and in vitro experiments, we identified two new antimalarials.
Original language | English (US) |
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Pages (from-to) | 10025-10027 |
Number of pages | 3 |
Journal | Chemical Communications |
Volume | 47 |
Issue number | 36 |
DOIs | |
State | Published - Sep 28 2011 |
ASJC Scopus subject areas
- Catalysis
- Electronic, Optical and Magnetic Materials
- Ceramics and Composites
- Chemistry(all)
- Surfaces, Coatings and Films
- Metals and Alloys
- Materials Chemistry