Characterization and application of the Fe(ii) and α-ketoglutarate dependent hydroxylase FrbJ

Matthew A. Desieno; Wilfred A. Van Der Donk; Huimin Zhao

doi:10.1039/c1cc13597j

Characterization and application of the Fe(ii) and α-ketoglutarate dependent hydroxylase FrbJ

Matthew A. Desieno, Wilfred A. Van Der Donk, Huimin Zhao

Research output: Contribution to journal › Article › peer-review

Abstract

The Fe(ii) and α-ketoglutarate-dependent hydroxylase FrbJ was previously demonstrated to utilize FR-900098 synthesizing a second phosphonate FR-33289. Here we assessed its ability to hydroxylate other possible substrates, generating a library of potential antimalarial compounds. Through a series of bioassays and in vitro experiments, we identified two new antimalarials.

Original language	English (US)
Pages (from-to)	10025-10027
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	36
DOIs	https://doi.org/10.1039/c1cc13597j
State	Published - Sep 28 2011

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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abstract = "The Fe(ii) and α-ketoglutarate-dependent hydroxylase FrbJ was previously demonstrated to utilize FR-900098 synthesizing a second phosphonate FR-33289. Here we assessed its ability to hydroxylate other possible substrates, generating a library of potential antimalarial compounds. Through a series of bioassays and in vitro experiments, we identified two new antimalarials.",

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