Characterization and application of the Fe(ii) and α-ketoglutarate dependent hydroxylase FrbJ

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Abstract

The Fe(ii) and α-ketoglutarate-dependent hydroxylase FrbJ was previously demonstrated to utilize FR-900098 synthesizing a second phosphonate FR-33289. Here we assessed its ability to hydroxylate other possible substrates, generating a library of potential antimalarial compounds. Through a series of bioassays and in vitro experiments, we identified two new antimalarials.

Original languageEnglish (US)
Pages (from-to)10025-10027
Number of pages3
JournalChemical Communications
Volume47
Issue number36
DOIs
StatePublished - Sep 28 2011

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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