Chapter 12 Gas Conduction of Lipid Bilayers and Membrane Channels

Yi Wang, Y. Zenmei Ohkubo, Emad Tajkhorshid

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Exchange of gas molecules across biological membranes constitutes one of the most fundamental phenomena in biology of aerobic organisms. The primary mechanism for gas conduction across the cellular membrane is deemed to be free diffusion of the species across lipid bilayers, however, the involvement of a number of membrane channels in the process has also been suggested. In this chapter we summarize the results of recent molecular dynamics simulations investigating the mechanism and pathways through which O2, CO2, and other biologically relevant gas species are exchanged between the two sides of the membrane. Different computational methodologies are employed, including explicit gas diffusion simulations where multiple copies of the gas species of interest are explicitly included in the simulation, under either equilibrium or biased chemical potential conditions, and implicit ligand sampling where the distribution of small, neutral ligands (gas molecules) inside membrane and/or a protein are deduced from the simulation of the ligand-free system. The results of simulations of pure lipid bilayers indicate that although the lipid bilayers are permeable by the gas species investigated, there is a significant barrier against gas permeation in the head-group layer. The barrier appears to be, at least partly, due to a tighter structure of water in the head-group region and can be markedly affected by changes in the head-group composition of the bilayer. In addition to lipid bilayers, several membrane channels were also investigated. Interestingly, almost all studied systems provide one or more pathways for gas conduction. Some of the identified gas conduction pathways are along the symmetry axis of oligomeric membrane channels, which might suggest the first functional implication for oligomerization of these proteins inside the membrane.

Original languageEnglish (US)
Title of host publicationComputational Modeling of Membrane Bilayers
EditorsScott Feller
Pages343-367
Number of pages25
DOIs
StatePublished - Jul 2 2008

Publication series

NameCurrent Topics in Membranes
Volume60
ISSN (Print)1063-5823

Fingerprint

Lipid Bilayers
Ion Channels
Gases
Membranes
Ligands
Molecular Dynamics Simulation
Membrane Proteins
Water

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

Wang, Y., Ohkubo, Y. Z., & Tajkhorshid, E. (2008). Chapter 12 Gas Conduction of Lipid Bilayers and Membrane Channels. In S. Feller (Ed.), Computational Modeling of Membrane Bilayers (pp. 343-367). (Current Topics in Membranes; Vol. 60). https://doi.org/10.1016/S1063-5823(08)00012-4

Chapter 12 Gas Conduction of Lipid Bilayers and Membrane Channels. / Wang, Yi; Ohkubo, Y. Zenmei; Tajkhorshid, Emad.

Computational Modeling of Membrane Bilayers. ed. / Scott Feller. 2008. p. 343-367 (Current Topics in Membranes; Vol. 60).

Research output: Chapter in Book/Report/Conference proceedingChapter

Wang, Y, Ohkubo, YZ & Tajkhorshid, E 2008, Chapter 12 Gas Conduction of Lipid Bilayers and Membrane Channels. in S Feller (ed.), Computational Modeling of Membrane Bilayers. Current Topics in Membranes, vol. 60, pp. 343-367. https://doi.org/10.1016/S1063-5823(08)00012-4
Wang Y, Ohkubo YZ, Tajkhorshid E. Chapter 12 Gas Conduction of Lipid Bilayers and Membrane Channels. In Feller S, editor, Computational Modeling of Membrane Bilayers. 2008. p. 343-367. (Current Topics in Membranes). https://doi.org/10.1016/S1063-5823(08)00012-4
Wang, Yi ; Ohkubo, Y. Zenmei ; Tajkhorshid, Emad. / Chapter 12 Gas Conduction of Lipid Bilayers and Membrane Channels. Computational Modeling of Membrane Bilayers. editor / Scott Feller. 2008. pp. 343-367 (Current Topics in Membranes).
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