Chapter 10 Methods for Evaluating Uteroplacental Angiogenesis and Their Application Using Animal Models

  • Pawel P. Borowicz
  • , Shireen Hafez
  • , Dale A. Redmer
  • , Lawrence P. Reynolds

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In this chapter, we present some of the compelling evidence confirming the importance of placental angiogenesis to fetal growth and development in normal and compromised pregnancies. We then describe the methodology that has been used to evaluate placental angiogenesis throughout pregnancy, including both the practical methods used to obtain reliable samples of the placental microcirculation as well as computerized methods used to analyze and reconstruct it. We then briefly describe the changes in placental angiogenesis and function in the models of normal and compromised pregnancy that we have used, and conclude with what we have learned from these studies and what we believe are the larger questions remaining.

Original languageEnglish (US)
Title of host publicationAngiogenesis
Subtitle of host publicationIn Vivo Systems, Part B
EditorsDavid Cheresh
Pages229-253
Number of pages25
DOIs
StatePublished - 2008
Externally publishedYes

Publication series

NameMethods in Enzymology
Volume445
ISSN (Print)0076-6879

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Fingerprint

Dive into the research topics of 'Chapter 10 Methods for Evaluating Uteroplacental Angiogenesis and Their Application Using Animal Models'. Together they form a unique fingerprint.

Cite this