Channeling to the Nucleus

Hee Jung Chung; Lily Y. Jan

doi:10.1016/j.neuron.2006.12.001

Channeling to the Nucleus

Hee Jung Chung
, Lily Y. Jan

Research output: Contribution to journal › Short survey › peer-review

Abstract

L-type voltage-gated calcium channels (LTCs) may control neuronal gene expression by increasing nuclear Ca²⁺ levels or regulating Ca²⁺/calmodulin-dependent transcription factors. In the November 3 issue of Cell, Gomez-Ospina et al. demonstrate another signaling mechanism, in which a C-terminal fragment of LTC translocates to the nucleus in a calcium-dependent manner and directly regulates transcription.

Original language	English (US)
Pages (from-to)	937-940
Number of pages	4
Journal	Neuron
Volume	52
Issue number	6
DOIs	https://doi.org/10.1016/j.neuron.2006.12.001
State	Published - Dec 21 2006
Externally published	Yes

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neuron.2006.12.001

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title = "Channeling to the Nucleus",

abstract = "L-type voltage-gated calcium channels (LTCs) may control neuronal gene expression by increasing nuclear Ca2+ levels or regulating Ca2+/calmodulin-dependent transcription factors. In the November 3 issue of Cell, Gomez-Ospina et al. demonstrate another signaling mechanism, in which a C-terminal fragment of LTC translocates to the nucleus in a calcium-dependent manner and directly regulates transcription.",

author = "Chung, \{Hee Jung\} and Jan, \{Lily Y.\}",

year = "2006",

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day = "21",

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journal = "Neuron",

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AU - Chung, Hee Jung

AU - Jan, Lily Y.

PY - 2006/12/21

Y1 - 2006/12/21

N2 - L-type voltage-gated calcium channels (LTCs) may control neuronal gene expression by increasing nuclear Ca2+ levels or regulating Ca2+/calmodulin-dependent transcription factors. In the November 3 issue of Cell, Gomez-Ospina et al. demonstrate another signaling mechanism, in which a C-terminal fragment of LTC translocates to the nucleus in a calcium-dependent manner and directly regulates transcription.

AB - L-type voltage-gated calcium channels (LTCs) may control neuronal gene expression by increasing nuclear Ca2+ levels or regulating Ca2+/calmodulin-dependent transcription factors. In the November 3 issue of Cell, Gomez-Ospina et al. demonstrate another signaling mechanism, in which a C-terminal fragment of LTC translocates to the nucleus in a calcium-dependent manner and directly regulates transcription.

UR - https://www.scopus.com/pages/publications/33845451964

UR - https://www.scopus.com/pages/publications/33845451964#tab=citedBy

U2 - 10.1016/j.neuron.2006.12.001

DO - 10.1016/j.neuron.2006.12.001

M3 - Short survey

C2 - 17178398

AN - SCOPUS:33845451964

SN - 0896-6273

VL - 52

SP - 937

EP - 940

JO - Neuron

JF - Neuron

IS - 6

ER -

Channeling to the Nucleus

Abstract

ASJC Scopus subject areas

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