Several experiments were performed to measure changes in serum triglycerides, retinoic acid, and retinol following removal of all-trans retinoic acid from the diet of rats previously fed 25 μg all-trans retinoic acid/g of diet for periods of 8-13 days. Inititally, rats had hypertriglyceridemia, but within 24-36 hours after withdrawal of retinoic acid, serum triglycerides returned to the level of control rats not fed retinoic acid. Serum retinoic acid also decreased after withdrawal, but did not return to the level of the control rats until 3 days afterwards. Serum retinol was depressed compared to the level of control rats until 72 hours after retinoic acid withdrawal. The fatty acid composition of the individual lipid fractions was shifted towards oleate and linoleate and away from palmitate and arachidonate after retinoic acid feeding. Following removal, restoration of a more normal pattern ensued.
- retinoic acid
- vitamin A
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Nutrition and Dietetics