Changes in serum triglycerides, retinoic acid, and retinol associated with with drawal of retinoic acid from the diet of rats

L. E. Gerber, L. S. Wasserman, B. H.S. Cho, John W Erdman

Research output: Contribution to journalArticle

Abstract

Several experiments were performed to measure changes in serum triglycerides, retinoic acid, and retinol following removal of all-trans retinoic acid from the diet of rats previously fed 25 μg all-trans retinoic acid/g of diet for periods of 8-13 days. Inititally, rats had hypertriglyceridemia, but within 24-36 hours after withdrawal of retinoic acid, serum triglycerides returned to the level of control rats not fed retinoic acid. Serum retinoic acid also decreased after withdrawal, but did not return to the level of the control rats until 3 days afterwards. Serum retinol was depressed compared to the level of control rats until 72 hours after retinoic acid withdrawal. The fatty acid composition of the individual lipid fractions was shifted towards oleate and linoleate and away from palmitate and arachidonate after retinoic acid feeding. Following removal, restoration of a more normal pattern ensued.

Original languageEnglish (US)
Pages (from-to)509-517
Number of pages9
JournalNutrition Research
Volume1
Issue number5
DOIs
StatePublished - 1981

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Tretinoin
Vitamin A
Triglycerides
Diet
Serum
Hypertriglyceridemia
Palmitates
Linoleic Acid
Oleic Acid
Fatty Acids
Lipids

Keywords

  • hyperlipidemia
  • retinoic acid
  • retinol
  • triglycerides
  • vitamin A

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

Cite this

Changes in serum triglycerides, retinoic acid, and retinol associated with with drawal of retinoic acid from the diet of rats. / Gerber, L. E.; Wasserman, L. S.; Cho, B. H.S.; Erdman, John W.

In: Nutrition Research, Vol. 1, No. 5, 1981, p. 509-517.

Research output: Contribution to journalArticle

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AU - Erdman, John W

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