Changes in quantitative ultrasound parameters during HIFU application

Goutam Ghoshal, Jeremy P. Kemmerer, Michael L. Oelze

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Quantitative ultrasound (QUS) is a novel imaging technique that is hypothesized to be capable of monitoring of High Intensity Focused Ultrasound (HIFU) treatment by quantifying tissue changes during exposure. Experiments were conducted on fresh liver samples from rats and lesions were formed using a HIFU system (1-MHz, f/1.2). A wire thermocouple was inserted into the sample to monitor temperature elevation. Backscattered time domain waveforms were recorded using a clinical imaging system (Ultrasonix, L14-5 linear array) during the HIFU application and backscatter coefficients were estimated using a reference phantom technique. Two parameters were estimated from the backscatter coefficient (effective scatterer diameter (ESD) and effective acoustic concentration (EAC)) and two parameters were estimated from the envelope statistics (k parameter and μ parameter) of the backscattered echoes. At the end of the exposure the ESD, EAC and k parameters changed in the treated region by 20%, 50% and 15% respectively, compared to the untreated region. Furthermore, changes in QUS parameters followed the shape of the temperature profile recorded by the thermocouple. These results suggest that QUS techniques could be used for noninvasive thermometry of HIFU.

Original languageEnglish (US)
Title of host publication11th International Symposium on Therapeutic Ultrasound
Number of pages6
StatePublished - 2012
Event11th International Symposium on Therapeutic Ultrasound, ISTU 2011 - New York, NY, United States
Duration: Apr 11 2011Apr 13 2011

Publication series

NameAIP Conference Proceedings
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616


Other11th International Symposium on Therapeutic Ultrasound, ISTU 2011
Country/TerritoryUnited States
CityNew York, NY


  • envelope statistics
  • HIFU
  • quantitative ultrasound
  • ultrasonic scattering

ASJC Scopus subject areas

  • General Physics and Astronomy


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