Changes in high-density lipoprotein-cholesterol subfractions with exercise training may be dependent on cholesteryl ester transfer protein (CETP) genotype

Kenneth R. Wilund, Robert E. Ferrell, Dana A. Phares, Andrew P. Goldberg, James M. Hagberg

Research output: Contribution to journalArticlepeer-review

Abstract

We sought to determine if a cholesteryl ester transfer protein (CETP) gene locus variation contributes to the variability in the responses of plasma high-density lipoprotein-cholesterol (HDL-C) and its subfractions to endurance exercise training. Middle- to older-aged men and women with at least 1 lipoprotein-lipid risk factor underwent 6 months of endurance exercise training while on a low-fat diet. Plasma lipid levels were measured by nuclear magnetic resonance (NMR). Initial age, body composition, lipoprotein-lipid profiles, and V̇o2max did not differ between the 2 CETP genotype groups (B1B1, n = 16; B1B2, n = 14). With exercise training, V̇o2max increased, and body weight, total body fat, and computed tomographic (CT) intra-abdominal visceral fat decreased similarly in both CETP genotype groups. Plasma total cholesterol and low-density lipoprotein-cholesterol (LDL-C) levels did not change significantly with training in either genotype group. HDL2NMR-C levels increased with exercise training in CETP B1B1 (P < .05), but did not change in CETP B1B2 genotype individuals. HDL3NMR-C levels tended to decrease with training in CETP B1B1 persons and HDL4NMR-C levels tended to increase with training somewhat more in CETP B1B2 individuals, but these differences were not significant. HDL5NMR-C levels increased similarly with exercise training in the 2 groups. The integrated HDL3-5NMR-C levels increased with exercise training in CETP B1B2 (P < .05), but did not change in CETP B1B1 genotype individuals. Apolipoprotein E (APO E) or lipoprotein lipase (LPL) PvuII genotype did not associate with HDL-C subfraction changes with training. Thus, CETP genotype may contribute to the interindividual differences in plasma HDL-C subfraction changes occurring with endurance exercise training in sedentary middle- to older-aged men and women.

Original languageEnglish (US)
Pages (from-to)774-778
Number of pages5
JournalMetabolism: Clinical and Experimental
Volume51
Issue number6
DOIs
StatePublished - 2002
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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