ChIP-seq is a powerful method for obtaining genome-wide maps of protein-DNA interactions and epigeneticmodications. CHANCE (CHip-seq ANalytics and Condence Estimation) is a standalone package for ChIP-seqquality control and protocol optimization. Our user-friendly graphical software quickly estimates the strengthand quality of immunoprecipitations, identies biases, compares the user's data with ENCODE's large collectionof published datasets, performs multi-sample normalization, checks against qPCR-validated control regions, andproduces informative graphical reports. CHANCE is available at https://github.com/songlab/chance.
ASJC Scopus subject areas
- Ecology, Evolution, Behavior and Systematics
- Cell Biology