Challenges in Terahertz Imaging of Freshly Excised Human Breast Tumors

Tyler Bowman; Magda El-Shenawee; Keith Bailey

doi:10.1109/APUSNCURSINRSM.2018.8608576

Challenges in Terahertz Imaging of Freshly Excised Human Breast Tumors

Tyler Bowman
, Magda El-Shenawee
, Keith Bailey

Veterinary Clinical Medicine

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Pulsed terahertz is investigated to image excised breast human tissue. Images of normal tissues obtained from breast reduction surgery are presented in addition to images of breast cancer tumors. Breast reduction tissue includes fat and fibroglandular regions, while malignant tumors include fat, fibroglandular and infiltrating ductal carcinoma regions. Breast tissue was received within 24 hours of surgery and was immersed in Dulbecco's Modified Eagle Medium solution, defined here as fresh tissue. The bulk tissue of the same tumor is then fixed in formalin and embedded in paraffin to be scanned on the terahertz system. Histopathology images of 3-4 μm hematoxylin and eosin stained sections sliced from the top of the fixed tissue block are presented for comparison with terahertz images. Results demonstrate good agreement between terahertz and pathology images, particularly for fixed tissues.

Original language	English (US)
Title of host publication	2018 IEEE Antennas and Propagation Society International Symposium and USNC/URSI National Radio Science Meeting, APSURSI 2018 - Proceedings
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	13-14
Number of pages	2
ISBN (Electronic)	9781538671023
DOIs	https://doi.org/10.1109/APUSNCURSINRSM.2018.8608576
State	Published - 2018
Event	2018 IEEE Antennas and Propagation Society International Symposium and USNC/URSI National Radio Science Meeting, APSURSI 2018 - Boston, United States Duration: Jul 8 2018 → Jul 13 2018

Publication series

Name	2018 IEEE Antennas and Propagation Society International Symposium and USNC/URSI National Radio Science Meeting, APSURSI 2018 - Proceedings

Conference

Conference	2018 IEEE Antennas and Propagation Society International Symposium and USNC/URSI National Radio Science Meeting, APSURSI 2018
Country/Territory	United States
City	Boston
Period	7/8/18 → 7/13/18

Keywords

Breast Cancer
Imaging
Infiltrating Ductal Carcinoma
Terahertz

ASJC Scopus subject areas

Computer Networks and Communications
Instrumentation
Radiation

Online availability

10.1109/APUSNCURSINRSM.2018.8608576

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Bowman, T., El-Shenawee, M., & Bailey, K. (2018). Challenges in Terahertz Imaging of Freshly Excised Human Breast Tumors. In 2018 IEEE Antennas and Propagation Society International Symposium and USNC/URSI National Radio Science Meeting, APSURSI 2018 - Proceedings (pp. 13-14). Article 8608576 (2018 IEEE Antennas and Propagation Society International Symposium and USNC/URSI National Radio Science Meeting, APSURSI 2018 - Proceedings). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/APUSNCURSINRSM.2018.8608576

Challenges in Terahertz Imaging of Freshly Excised Human Breast Tumors. / Bowman, Tyler; El-Shenawee, Magda; Bailey, Keith.
2018 IEEE Antennas and Propagation Society International Symposium and USNC/URSI National Radio Science Meeting, APSURSI 2018 - Proceedings. Institute of Electrical and Electronics Engineers Inc., 2018. p. 13-14 8608576 (2018 IEEE Antennas and Propagation Society International Symposium and USNC/URSI National Radio Science Meeting, APSURSI 2018 - Proceedings).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Bowman, T, El-Shenawee, M & Bailey, K 2018, Challenges in Terahertz Imaging of Freshly Excised Human Breast Tumors. in 2018 IEEE Antennas and Propagation Society International Symposium and USNC/URSI National Radio Science Meeting, APSURSI 2018 - Proceedings., 8608576, 2018 IEEE Antennas and Propagation Society International Symposium and USNC/URSI National Radio Science Meeting, APSURSI 2018 - Proceedings, Institute of Electrical and Electronics Engineers Inc., pp. 13-14, 2018 IEEE Antennas and Propagation Society International Symposium and USNC/URSI National Radio Science Meeting, APSURSI 2018, Boston, United States, 7/8/18. https://doi.org/10.1109/APUSNCURSINRSM.2018.8608576

Bowman T, El-Shenawee M, Bailey K. Challenges in Terahertz Imaging of Freshly Excised Human Breast Tumors. In 2018 IEEE Antennas and Propagation Society International Symposium and USNC/URSI National Radio Science Meeting, APSURSI 2018 - Proceedings. Institute of Electrical and Electronics Engineers Inc. 2018. p. 13-14. 8608576. (2018 IEEE Antennas and Propagation Society International Symposium and USNC/URSI National Radio Science Meeting, APSURSI 2018 - Proceedings). doi: 10.1109/APUSNCURSINRSM.2018.8608576

Bowman, Tyler ; El-Shenawee, Magda ; Bailey, Keith. / Challenges in Terahertz Imaging of Freshly Excised Human Breast Tumors. 2018 IEEE Antennas and Propagation Society International Symposium and USNC/URSI National Radio Science Meeting, APSURSI 2018 - Proceedings. Institute of Electrical and Electronics Engineers Inc., 2018. pp. 13-14 (2018 IEEE Antennas and Propagation Society International Symposium and USNC/URSI National Radio Science Meeting, APSURSI 2018 - Proceedings).

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title = "Challenges in Terahertz Imaging of Freshly Excised Human Breast Tumors",

abstract = "Pulsed terahertz is investigated to image excised breast human tissue. Images of normal tissues obtained from breast reduction surgery are presented in addition to images of breast cancer tumors. Breast reduction tissue includes fat and fibroglandular regions, while malignant tumors include fat, fibroglandular and infiltrating ductal carcinoma regions. Breast tissue was received within 24 hours of surgery and was immersed in Dulbecco's Modified Eagle Medium solution, defined here as fresh tissue. The bulk tissue of the same tumor is then fixed in formalin and embedded in paraffin to be scanned on the terahertz system. Histopathology images of 3-4 μm hematoxylin and eosin stained sections sliced from the top of the fixed tissue block are presented for comparison with terahertz images. Results demonstrate good agreement between terahertz and pathology images, particularly for fixed tissues.",

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author = "Tyler Bowman and Magda El-Shenawee and Keith Bailey",

note = "This work was funded by NIH award \# R15CA208798. It was also funded in part by NSF award \#1408007. Funding for the pulsed THz system was obtained through NSF/MRI award \#1228958.; 2018 IEEE Antennas and Propagation Society International Symposium and USNC/URSI National Radio Science Meeting, APSURSI 2018 ; Conference date: 08-07-2018 Through 13-07-2018",

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AU - Bowman, Tyler

AU - El-Shenawee, Magda

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PY - 2018

Y1 - 2018

N2 - Pulsed terahertz is investigated to image excised breast human tissue. Images of normal tissues obtained from breast reduction surgery are presented in addition to images of breast cancer tumors. Breast reduction tissue includes fat and fibroglandular regions, while malignant tumors include fat, fibroglandular and infiltrating ductal carcinoma regions. Breast tissue was received within 24 hours of surgery and was immersed in Dulbecco's Modified Eagle Medium solution, defined here as fresh tissue. The bulk tissue of the same tumor is then fixed in formalin and embedded in paraffin to be scanned on the terahertz system. Histopathology images of 3-4 μm hematoxylin and eosin stained sections sliced from the top of the fixed tissue block are presented for comparison with terahertz images. Results demonstrate good agreement between terahertz and pathology images, particularly for fixed tissues.

AB - Pulsed terahertz is investigated to image excised breast human tissue. Images of normal tissues obtained from breast reduction surgery are presented in addition to images of breast cancer tumors. Breast reduction tissue includes fat and fibroglandular regions, while malignant tumors include fat, fibroglandular and infiltrating ductal carcinoma regions. Breast tissue was received within 24 hours of surgery and was immersed in Dulbecco's Modified Eagle Medium solution, defined here as fresh tissue. The bulk tissue of the same tumor is then fixed in formalin and embedded in paraffin to be scanned on the terahertz system. Histopathology images of 3-4 μm hematoxylin and eosin stained sections sliced from the top of the fixed tissue block are presented for comparison with terahertz images. Results demonstrate good agreement between terahertz and pathology images, particularly for fixed tissues.

KW - Breast Cancer

KW - Imaging

KW - Infiltrating Ductal Carcinoma

KW - Terahertz

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Challenges in Terahertz Imaging of Freshly Excised Human Breast Tumors

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