Challenges and opportunities in synthetic biology for chemical engineers

Yunzi Luo; Jung Kul Lee; Huimin Zhao

doi:10.1016/j.ces.2012.06.013

Challenges and opportunities in synthetic biology for chemical engineers

Yunzi Luo, Jung Kul Lee, Huimin Zhao

Research output: Contribution to journal › Article › peer-review

Abstract

Synthetic biology provides numerous great opportunities for chemical engineers in the development of new processes for large-scale production of biofuels, value-added chemicals, and protein therapeutics. However, challenges across all scales abound. In particular, the modularization and standardization of the components in a biological system, so-called biological parts, remain the biggest obstacle in synthetic biology. In this perspective, we will discuss the main challenges and opportunities in the rapidly growing synthetic biology field and the important roles that chemical engineers can play in its advancement.

Original language	English (US)
Pages (from-to)	115-119
Number of pages	5
Journal	Chemical Engineering Science
Volume	103
DOIs	https://doi.org/10.1016/j.ces.2012.06.013
State	Published - Nov 5 2013

Keywords

Biocatalysis
Biochemical engineering
Biotechnology
Metabolic engineering
Protein engineering
Synthetic biology

ASJC Scopus subject areas

Chemical Engineering(all)
Chemistry(all)
Applied Mathematics
Industrial and Manufacturing Engineering

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@article{831eadfbdb784231aac10401f3df623f,

title = "Challenges and opportunities in synthetic biology for chemical engineers",

abstract = "Synthetic biology provides numerous great opportunities for chemical engineers in the development of new processes for large-scale production of biofuels, value-added chemicals, and protein therapeutics. However, challenges across all scales abound. In particular, the modularization and standardization of the components in a biological system, so-called biological parts, remain the biggest obstacle in synthetic biology. In this perspective, we will discuss the main challenges and opportunities in the rapidly growing synthetic biology field and the important roles that chemical engineers can play in its advancement.",

keywords = "Biocatalysis, Biochemical engineering, Biotechnology, Metabolic engineering, Protein engineering, Synthetic biology",

author = "Yunzi Luo and Lee, {Jung Kul} and Huimin Zhao",

note = "Funding Information: We thank the National Institutes of Health ( GM077596 ), the National Academies Keck Futures Initiative on Synthetic Biology , the Energy Biosciences Institute , the Department of Energy under Advanced Research Projects Agency-Energy (ARPA-E) ( DE-AR0000206 ), and the National Science Foundation as part of the Center for Enabling New Technologies through Catalysis (CENTC) , CHE-0650456 for financial support in our synthetic biology projects. Y. Luo also acknowledges fellowship support from the National Research Foundation of Korea (NRFK) ( 220–2009-1-D00033 ).",

year = "2013",

month = nov,

day = "5",

doi = "10.1016/j.ces.2012.06.013",

language = "English (US)",

volume = "103",

pages = "115--119",

journal = "Chemical Engineering Science",

issn = "0009-2509",

publisher = "Elsevier BV",

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T1 - Challenges and opportunities in synthetic biology for chemical engineers

AU - Luo, Yunzi

AU - Lee, Jung Kul

AU - Zhao, Huimin

N1 - Funding Information: We thank the National Institutes of Health ( GM077596 ), the National Academies Keck Futures Initiative on Synthetic Biology , the Energy Biosciences Institute , the Department of Energy under Advanced Research Projects Agency-Energy (ARPA-E) ( DE-AR0000206 ), and the National Science Foundation as part of the Center for Enabling New Technologies through Catalysis (CENTC) , CHE-0650456 for financial support in our synthetic biology projects. Y. Luo also acknowledges fellowship support from the National Research Foundation of Korea (NRFK) ( 220–2009-1-D00033 ).

PY - 2013/11/5

Y1 - 2013/11/5

N2 - Synthetic biology provides numerous great opportunities for chemical engineers in the development of new processes for large-scale production of biofuels, value-added chemicals, and protein therapeutics. However, challenges across all scales abound. In particular, the modularization and standardization of the components in a biological system, so-called biological parts, remain the biggest obstacle in synthetic biology. In this perspective, we will discuss the main challenges and opportunities in the rapidly growing synthetic biology field and the important roles that chemical engineers can play in its advancement.

AB - Synthetic biology provides numerous great opportunities for chemical engineers in the development of new processes for large-scale production of biofuels, value-added chemicals, and protein therapeutics. However, challenges across all scales abound. In particular, the modularization and standardization of the components in a biological system, so-called biological parts, remain the biggest obstacle in synthetic biology. In this perspective, we will discuss the main challenges and opportunities in the rapidly growing synthetic biology field and the important roles that chemical engineers can play in its advancement.

KW - Biocatalysis

KW - Biochemical engineering

KW - Biotechnology

KW - Metabolic engineering

KW - Protein engineering

KW - Synthetic biology

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