Challenges and opportunities in C1-based biomanufacturing

Weibo Qiao, Shijie Xu, Zihe Liu, Xiaoying Fu, Huimin Zhao, Shuobo Shi

Research output: Contribution to journalReview articlepeer-review


The intensifying impact of green-house gas (GHG) emission on environment and climate change has attracted increasing attention, and biorefinery represents one of the most effective routes for reducing GHG emissions from human activities. However, this requires a shift for microbial fermentation from the current use of sugars to the use of biomass, and even better to the primary fixation of single carbon (C1) compounds. Here how microorganisms can be engineered for fixation and conversion of C1 compounds into metabolites that can serve as fuels and platform chemicals are reviewed. Meanwhile, key factors for utilization of these different pathways are discussed, followed by challenges and barriers for the development of C1-based biorefinery.

Original languageEnglish (US)
Article number128095
JournalBioresource Technology
StatePublished - Nov 2022


  • C1-based biorefinery
  • Metabolic engineering
  • Metabolic networks and pathways
  • Synthetic biology

ASJC Scopus subject areas

  • Bioengineering
  • Waste Management and Disposal
  • Environmental Engineering
  • Renewable Energy, Sustainability and the Environment


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