TY - JOUR
T1 - Challenges and opportunities in C1-based biomanufacturing
AU - Qiao, Weibo
AU - Xu, Shijie
AU - Liu, Zihe
AU - Fu, Xiaoying
AU - Zhao, Huimin
AU - Shi, Shuobo
N1 - This work was supported by the National Key Research and Development Program of China [2018YFA0900100], the China Postdoctoral Science Foundation [2021M690321], and the Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology.
PY - 2022/11
Y1 - 2022/11
N2 - The intensifying impact of green-house gas (GHG) emission on environment and climate change has attracted increasing attention, and biorefinery represents one of the most effective routes for reducing GHG emissions from human activities. However, this requires a shift for microbial fermentation from the current use of sugars to the use of biomass, and even better to the primary fixation of single carbon (C1) compounds. Here how microorganisms can be engineered for fixation and conversion of C1 compounds into metabolites that can serve as fuels and platform chemicals are reviewed. Meanwhile, key factors for utilization of these different pathways are discussed, followed by challenges and barriers for the development of C1-based biorefinery.
AB - The intensifying impact of green-house gas (GHG) emission on environment and climate change has attracted increasing attention, and biorefinery represents one of the most effective routes for reducing GHG emissions from human activities. However, this requires a shift for microbial fermentation from the current use of sugars to the use of biomass, and even better to the primary fixation of single carbon (C1) compounds. Here how microorganisms can be engineered for fixation and conversion of C1 compounds into metabolites that can serve as fuels and platform chemicals are reviewed. Meanwhile, key factors for utilization of these different pathways are discussed, followed by challenges and barriers for the development of C1-based biorefinery.
KW - C1-based biorefinery
KW - Metabolic engineering
KW - Metabolic networks and pathways
KW - Synthetic biology
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U2 - 10.1016/j.biortech.2022.128095
DO - 10.1016/j.biortech.2022.128095
M3 - Review article
C2 - 36220528
AN - SCOPUS:85140020276
SN - 0960-8524
VL - 364
JO - Bioresource Technology
JF - Bioresource Technology
M1 - 128095
ER -