Chain-shattering polymeric therapeutics with on-demand drug-release capability

Yanfeng Zhang, Qian Yin, Lichen Yin, Liang Ma, Li Tang, Jianjun Cheng

Research output: Contribution to journalArticlepeer-review

Abstract

Trigger happy: Trigger-responsive chain-shattering polymeric therapeutics (CSPTs) were prepared by condensation polymerization of a UV- or hydrogen peroxide-responsive domain and a drug as co-monomers. Drug release can be started and stopped by starting and stopping the trigger treatment. Chemotherapeutic-containing CSPTs showed trigger-responsive in vitro and in vivo antitumor efficacy.

Original languageEnglish (US)
Pages (from-to)6435-6439
Number of pages5
JournalAngewandte Chemie - International Edition
Volume52
Issue number25
DOIs
StatePublished - Jun 17 2013

Keywords

  • cancer therapy
  • controlled release
  • polymer-drug conjugate
  • polymers
  • trigger-responsive polymer

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

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