Abstract
Trigger happy: Trigger-responsive chain-shattering polymeric therapeutics (CSPTs) were prepared by condensation polymerization of a UV- or hydrogen peroxide-responsive domain and a drug as co-monomers. Drug release can be started and stopped by starting and stopping the trigger treatment. Chemotherapeutic-containing CSPTs showed trigger-responsive in vitro and in vivo antitumor efficacy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 6435-6439 |
| Number of pages | 5 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 52 |
| Issue number | 25 |
| DOIs | |
| State | Published - Jun 17 2013 |
| Externally published | Yes |
Keywords
- cancer therapy
- controlled release
- polymer-drug conjugate
- polymers
- trigger-responsive polymer
ASJC Scopus subject areas
- Chemistry(all)
- Catalysis