Chain-length dependence of the protein and cell resistance of oligo(ethylene glycol)-terminated self-assembled monolayers on gold

Boru Zhu, Thomas Eurell, Rico Gunawan, Deborah Leckband

Research output: Contribution to journalArticle

Abstract

Oligo(ethylene glycol) (O-EGn)-terminated alkanethiol surface-assembled monolayers (SAMs) have been reported to demonstrate protein-resistant properties similar to those of poly(ethylene glycol) (PEG). In this study, we compared the relative protein resistance of short and long ethylene oxide chains, SAMs of PEG 5000, PEG 2000, O-EG3 (molecular weight = 120), and O-EG6 (molecular weight = 240), on gold surfaces. Surface plasmon resonance showed that these monolayers were all protein-resistant within the uncertainty of the measurement. However, they exhibited different adhesive properties toward 3T3 mouse fibroblast adhesion in supplemented Dulbecco's modified Eagles medium. The results show that the cell adhesion was sensitive to the concentration of proteins supplemented in the culture medium and to the length of PEG chains.

Original languageEnglish (US)
Pages (from-to)406-416
Number of pages11
JournalJournal of Biomedical Materials Research
Volume56
Issue number3
DOIs
StatePublished - Sep 5 2001

Fingerprint

Ethylene Glycol
Self assembled monolayers
Ethylene glycol
Chain length
Gold
Polyethylene glycols
Proteins
Monolayers
Molecular weight
Ethylene Oxide
Cell adhesion
Surface plasmon resonance
Fibroblasts
Culture Media
Adhesives
Ethylene
Adhesion
Oxides

Keywords

  • Oligo(ethylene glycol)
  • Poly(ethylene glycol)
  • Protein resistance
  • Self-assembled monolayer

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials

Cite this

Chain-length dependence of the protein and cell resistance of oligo(ethylene glycol)-terminated self-assembled monolayers on gold. / Zhu, Boru; Eurell, Thomas; Gunawan, Rico; Leckband, Deborah.

In: Journal of Biomedical Materials Research, Vol. 56, No. 3, 05.09.2001, p. 406-416.

Research output: Contribution to journalArticle

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