TY - JOUR
T1 - Chain-length dependence of the protein and cell resistance of oligo(ethylene glycol)-terminated self-assembled monolayers on gold
AU - Zhu, Boru
AU - Eurell, Thomas
AU - Gunawan, Rico
AU - Leckband, Deborah
PY - 2001/9/5
Y1 - 2001/9/5
N2 - Oligo(ethylene glycol) (O-EGn)-terminated alkanethiol surface-assembled monolayers (SAMs) have been reported to demonstrate protein-resistant properties similar to those of poly(ethylene glycol) (PEG). In this study, we compared the relative protein resistance of short and long ethylene oxide chains, SAMs of PEG 5000, PEG 2000, O-EG3 (molecular weight = 120), and O-EG6 (molecular weight = 240), on gold surfaces. Surface plasmon resonance showed that these monolayers were all protein-resistant within the uncertainty of the measurement. However, they exhibited different adhesive properties toward 3T3 mouse fibroblast adhesion in supplemented Dulbecco's modified Eagles medium. The results show that the cell adhesion was sensitive to the concentration of proteins supplemented in the culture medium and to the length of PEG chains.
AB - Oligo(ethylene glycol) (O-EGn)-terminated alkanethiol surface-assembled monolayers (SAMs) have been reported to demonstrate protein-resistant properties similar to those of poly(ethylene glycol) (PEG). In this study, we compared the relative protein resistance of short and long ethylene oxide chains, SAMs of PEG 5000, PEG 2000, O-EG3 (molecular weight = 120), and O-EG6 (molecular weight = 240), on gold surfaces. Surface plasmon resonance showed that these monolayers were all protein-resistant within the uncertainty of the measurement. However, they exhibited different adhesive properties toward 3T3 mouse fibroblast adhesion in supplemented Dulbecco's modified Eagles medium. The results show that the cell adhesion was sensitive to the concentration of proteins supplemented in the culture medium and to the length of PEG chains.
KW - Oligo(ethylene glycol)
KW - Poly(ethylene glycol)
KW - Protein resistance
KW - Self-assembled monolayer
UR - http://www.scopus.com/inward/record.url?scp=0035812494&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035812494&partnerID=8YFLogxK
U2 - 10.1002/1097-4636(20010905)56:3<406::AID-JBM1110>3.0.CO;2-R
DO - 10.1002/1097-4636(20010905)56:3<406::AID-JBM1110>3.0.CO;2-R
M3 - Article
C2 - 11372059
AN - SCOPUS:0035812494
SN - 0021-9304
VL - 56
SP - 406
EP - 416
JO - Journal of Biomedical Materials Research
JF - Journal of Biomedical Materials Research
IS - 3
ER -