Central interleukin-1 receptors as mediators of sickness

Keith W. Kelley, Kevin Hutchison, Richard French, Rose Marie Bluthé, Patricia Parnet, Rodney W. Johnson, Robert Dantzer

Research output: Contribution to journalArticlepeer-review


These data establish that cytokines, such as IL-1, can act on specific receptors within the brain to induce many symptoms of sickness. A number of inflammatory stimuli in the periphery can activate both the transcription and translation of IL-1 within the central nervous system. It will now be important to determine if similar central IL-1 pathways are activated during SLE and whether these central inflammatory cytokines are involved in the neurologic complications that often accompany this disease.

Original languageEnglish (US)
Pages (from-to)234-246
Number of pages13
JournalAnnals of the New York Academy of Sciences
StatePublished - 1997

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science


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