Central administration of insulin-like growth factor-1 inhibits lipopolysaccharide-induced sickness behavior in mice

Robert Dantzer, Gilles Gheusi, Rodney W. Johnson, Keith W. Kelley

Research output: Contribution to journalArticle

Abstract

To assess the possible modulatory effects of insulin-like growth factor- 1 (IGF-1) on the brain effects of proinflammatory cytokines, male CD-1 mice were injected into the lateral ventricle of the brain with a behaviorally depressing dose (100 ng) of the cytokine inducer lipopolysaccharide (LPS) and their response to various doses of IGF-1 (0, 100 and 1000 ng) was measured during behavioral tests carried before and at various time intervals after treatment. LPS induced a profound behavioral depression that was abrogated by the higher dose of IGF-1 tested. Since the behavioral effects of LPS are mediated by the local synthesis and results of proinflammatory cytokines, these results indicate that IGF-1 interferes with the production and/or action of proinflammatory cytokines in the brain.

Original languageEnglish (US)
Pages (from-to)289-292
Number of pages4
JournalNeuroreport
Volume10
Issue number2
DOIs
StatePublished - Feb 5 1999

Keywords

  • Behavior
  • Brain
  • Insulin-like growth factor-1
  • Lipopolysaccharide
  • Mice

ASJC Scopus subject areas

  • Neuroscience(all)

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