@article{875c5397a12748fb9d3122439d11012c,
title = "Central action and a species comparison of the estrogenic effects of an antiestrogen on eating and body weight",
abstract = "The antiestrogen MER-25, which generally inhibits estradiol-induced behavior, is itself fully estrogenic on eating and body weight. In rats, MER-25 decreases food intake when implanted in the same hypothalamic areas in which estradiol decreases food intake. In gerbils, both estradiol benzoate and MER-25 cause increased food intake and body weight.",
keywords = "Antiestrogen, Body weight, Eating, Gerbils, Intracerebral hormone implants, MER-25",
author = "Roy, {Edward J.} and Maass, {Christie A.} and Wade, {George N.}",
note = "Funding Information: Thirty adult female Mongolian gerbils were obtained from Tumblebrook Farms, North Brookfield, Massachusetts. They were ovariectomized under methoxyfluranc (Metofane) anesthesia. Animals were fed Purina Laboratory Chow, and maintained on a 12:12 lighting cycle. They were housed individually, and body weight and food intake with spillage were measured to the nearest .1 g twice a week. Five weeks after surgery the animals were divided into four groups. Daily SC injections of the following compounds were administered for four weeks: 4 mg MER-25 (M: n = 7), 4 mg MER-25 plus 1 mg progesterone (MP; n = 8), 4 mg MER-25 plus 2 ~g EB plus 1 mg P (MEP; n = 7), or the sesame oil vehicle (O; n = 8). All injections were. 1 ml. The effects of MER-25 in combination with P and EP were of interest, since in OVX gerbils progesterone augments the effects of EB on eating while having little or no effect when given alone \[13\]. The MP group might facilitate detection of an estrogenic effect of MER-25, whereas the MEP group would optimize the chances of observing an antagonislic action of MER-25. Analyses were performed on the difference between individuals' mean food intake or body ~This research was supported in part by Research Grant NS10873, Research Career Development Award NS-00090 from the National Institute of Neurological Diseases and Stroke, and Training Grant MHl1823 from the National Institutes of Health. We grateful\[.v acknowledge the technical assistance of Elizabeth Silver and the nontechnical assistance of R. Thomas Gentry and J. D. Blaustein. MER-25 (ethamoxytriphetol) was generously supplied by Dr. Alfred Richardson, Jr. of Merrell National Laboratories. Estradiol benzoate and progesterone were supplied by the Schering Corporation. 2 Present address: The Rockefeller University, New York, NY 10021. 3 Send reprint requests to George N. Wade.",
year = "1977",
month = jan,
doi = "10.1016/0031-9384(77)90105-6",
language = "English (US)",
volume = "18",
pages = "137--140",
journal = "Physiology and Behavior",
issn = "0031-9384",
publisher = "Elsevier Inc.",
number = "1",
}