Cellular tensegrity models and cell-substrate interactions

Dimitrije Stamenović, Ning Wang, Donald E. Ingber

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter discusses how living cells use a tensegrity mechanism to sense, respond, and adapt to changes in their mechanical environment, including stresses applied at the cell-extracellular matrix (ECM) interface. Mechanotransduction, the cellular response to mechanical stress, is governed by the cytoskeleton (CSK), a molecular network composed of different types of biopolymers that mechanically stabilizes the cell and actively generates contractile forces. Mechanical distortion of cell shape can impact many cell biological behaviors, including motility, contractility, growth, differentiation, and apoptosis. Mechanical distortion of cells produces these changes in cell function by inducing restructuring of the CSK and thereby impacting cellular biochemistry and gene expression through largely unknown mechanisms. Tensegrity architecture describes a class of discrete network structures that maintain their structural integrity because of prestress in their cable-like structural members. A unique property of tensegrity structures is that a mechanical stress may be transferred over long distances within the tensionally linked structural network, a phenomenon referred to as "action at a distance.".

Original languageEnglish (US)
Title of host publicationPrinciples of Cellular Engineering
PublisherElsevier Inc.
Pages81-101
Number of pages21
ISBN (Print)9780123693921
DOIs
StatePublished - Dec 1 2006
Externally publishedYes

Fingerprint

Cell Communication
Substrates
Mechanical Stress
Biochemistry
Biopolymers
Structural members
Structural integrity
Cytoskeleton
Gene expression
Cellular Mechanotransduction
Cables
Cells
Apoptosis
Cell Shape
Extracellular Matrix
Gene Expression
Growth

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Stamenović, D., Wang, N., & Ingber, D. E. (2006). Cellular tensegrity models and cell-substrate interactions. In Principles of Cellular Engineering (pp. 81-101). Elsevier Inc.. https://doi.org/10.1016/B978-012369392-1/50005-X

Cellular tensegrity models and cell-substrate interactions. / Stamenović, Dimitrije; Wang, Ning; Ingber, Donald E.

Principles of Cellular Engineering. Elsevier Inc., 2006. p. 81-101.

Research output: Chapter in Book/Report/Conference proceedingChapter

Stamenović, D, Wang, N & Ingber, DE 2006, Cellular tensegrity models and cell-substrate interactions. in Principles of Cellular Engineering. Elsevier Inc., pp. 81-101. https://doi.org/10.1016/B978-012369392-1/50005-X
Stamenović D, Wang N, Ingber DE. Cellular tensegrity models and cell-substrate interactions. In Principles of Cellular Engineering. Elsevier Inc. 2006. p. 81-101 https://doi.org/10.1016/B978-012369392-1/50005-X
Stamenović, Dimitrije ; Wang, Ning ; Ingber, Donald E. / Cellular tensegrity models and cell-substrate interactions. Principles of Cellular Engineering. Elsevier Inc., 2006. pp. 81-101
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