Cellular-scale hydrodynamics

Manouk Abkarian, Magalie Faivre, Renita Horton, Kristian Smistrup, Catherine A. Best-Popescu, Howard A. Stone

Research output: Contribution to journalArticle

Abstract

Microfluidic tools are providing many new insights into the chemical, physical and physicochemical responses of cells. Both suspension-level and single-cell measurements have been studied. We review our studies of these kinds of problems for red blood cells with particular focus on the shapes of individual cells in confined geometries, the development and use of a 'differential manometer' for evaluating the mechanical response of individual cells or other objects flowing in confined geometries, and the cross-streamline drift of cells that pass through a constriction. In particular, we show how fluid mechanical effects on suspended cells can be studied systematically in small devices, and how these features can be exploited to develop methods for characterizing physicochemical responses and possibly for the diagnosis of cellular-scale changes to environmental factors.

Original languageEnglish (US)
Article number034011
JournalBiomedical Materials
Volume3
Issue number3
DOIs
StatePublished - Sep 1 2008

ASJC Scopus subject areas

  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

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    Abkarian, M., Faivre, M., Horton, R., Smistrup, K., Best-Popescu, C. A., & Stone, H. A. (2008). Cellular-scale hydrodynamics. Biomedical Materials, 3(3), [034011]. https://doi.org/10.1088/1748-6041/3/3/034011