Cellular and neoplastic tissue imaging with optical coherence tomography

Costas Pitris, Stephen Allen Boppart, Mark E. Brezinski, Brett E. Bouma, James G. Fujimoto

Research output: Chapter in Book/Report/Conference proceedingConference contribution


The ability of optical coherence tomography (OCT) to image cellular morphology in vivo was evaluated using an animal model. Images were acquired perpendicular to the anteroposterior axis of Xenopus laevis (African frog tadpole). Detailed cellular morphology, including cell membranes and individual cell nuclei, was easily visible using high resolution OCT. Individual cells were also imaged through the cell cycle demonstrating in vivo imaging of cellular processes such as mitosis. OCT imaging in vitro was also performed on a series of human tissues of varying degrees of neoplastic infiltration. The data obtained suggests that OCT-guided diagnosis has the potential to provide early detection of neoplasia and aid the prompt and efficient treatment of cancer.

Original languageEnglish (US)
Title of host publicationConference on Lasers and Electro-Optics Europe - Technical Digest
Editors Anon
Number of pages2
StatePublished - 1998
Externally publishedYes
EventProceedings of the 1998 Conference on Lasers and Electro-Optics, CLEO - San Francisco, CA, USA
Duration: May 3 1998May 8 1998


OtherProceedings of the 1998 Conference on Lasers and Electro-Optics, CLEO
CitySan Francisco, CA, USA

ASJC Scopus subject areas

  • Control and Systems Engineering
  • Electrical and Electronic Engineering


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