TY - JOUR
T1 - Cellular and molecular basis of liver regeneration
AU - Bangru, Sushant
AU - Kalsotra, Auinash
N1 - A.K. is supported by grants from the US National Institute of Health ( R01HL126845 , R01AA010154 ), Muscular Dystrophy Association ( MDA514335 ), Planning Grant Award from the Cancer Center at Illinois , and Beckman Fellowship from the Center for Advanced Study at the University of Illinois Urbana-Champaign . S.B is supported by the NIH Tissue microenvironment training program ( T32-EB019944 ). We sincerely apologize to colleagues whose work was not discussed in this review because of space constraints.
PY - 2020/4
Y1 - 2020/4
N2 - Recent advances in genetics and genomics have reinvigorated the field of liver regeneration. It is now possible to combine lineage-tracing with genome-wide studies to genetically mark individual liver cells and their progenies and detect precise changes in their genome, transcriptome, and proteome under normal versus regenerative settings. The recent use of single-cell RNA sequencing methodologies in model organisms has, in some ways, transformed our understanding of the cellular and molecular biology of liver regeneration. Here, we review the latest strides in our knowledge of general principles that coordinate regeneration of the liver and reflect on some conflicting evidence and controversies surrounding this topic. We consider the prominent mechanisms that stimulate homeostasis-related vis-à-vis injury-driven regenerative responses, highlight the likely cellular sources/depots that reconstitute the liver following various injuries and discuss the extrinsic and intrinsic signals that direct liver cells to proliferate, de-differentiate, or trans-differentiate while the tissue recovers from acute or chronic damage.
AB - Recent advances in genetics and genomics have reinvigorated the field of liver regeneration. It is now possible to combine lineage-tracing with genome-wide studies to genetically mark individual liver cells and their progenies and detect precise changes in their genome, transcriptome, and proteome under normal versus regenerative settings. The recent use of single-cell RNA sequencing methodologies in model organisms has, in some ways, transformed our understanding of the cellular and molecular biology of liver regeneration. Here, we review the latest strides in our knowledge of general principles that coordinate regeneration of the liver and reflect on some conflicting evidence and controversies surrounding this topic. We consider the prominent mechanisms that stimulate homeostasis-related vis-à-vis injury-driven regenerative responses, highlight the likely cellular sources/depots that reconstitute the liver following various injuries and discuss the extrinsic and intrinsic signals that direct liver cells to proliferate, de-differentiate, or trans-differentiate while the tissue recovers from acute or chronic damage.
KW - Hepatocellular plasticity
KW - Lineage-tracing
KW - Liver injury and repair
KW - Single-cell RNA sequencing
KW - Transcriptional and post-transcriptional gene regulation
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U2 - 10.1016/j.semcdb.2019.12.004
DO - 10.1016/j.semcdb.2019.12.004
M3 - Review article
C2 - 31980376
AN - SCOPUS:85078208110
SN - 1084-9521
VL - 100
SP - 74
EP - 87
JO - Seminars in Cell and Developmental Biology
JF - Seminars in Cell and Developmental Biology
ER -