TY - GEN
T1 - CELLS DECIPHER THE INTEGRATED CHEMICAL AND FLUIDIC CUES AS TERNARY LOGIC PROCESSOR FOR DIRECTED MIGRATION
AU - Moon, Hye Ran
AU - Saha, Soutick
AU - Mugler, Andrew J.
AU - Han, Bumsoo
N1 - This work was partially supported by grants from the National Institutes of Health (U01 HL143403, R01 CA254110, R61 HL 159948, and P30 CA023168) and National Science Foundation (MCB-2134603, MCB-1936761, and PHY-1945018).
PY - 2022
Y1 - 2022
N2 - Cells sense and process various environmental cues to decide their migration direction. Although several signaling molecules have been identified for a given cue, it still remains elusive how cells decipher multiple cues, specifically chemical and fluidic cues. In this study, we reverse-engineered the cellular signal processing machinery by exposing controlled chemical and fluidic cues to cells using a microfluidic platform. The results were analyzed to define the extra-cellular interaction of chemical and fluidic cues and to build the cell's intrinsic signal processing system. The proposed framework suggests a systematic approach to understand how cells decode multiple cues to make decisions.
AB - Cells sense and process various environmental cues to decide their migration direction. Although several signaling molecules have been identified for a given cue, it still remains elusive how cells decipher multiple cues, specifically chemical and fluidic cues. In this study, we reverse-engineered the cellular signal processing machinery by exposing controlled chemical and fluidic cues to cells using a microfluidic platform. The results were analyzed to define the extra-cellular interaction of chemical and fluidic cues and to build the cell's intrinsic signal processing system. The proposed framework suggests a systematic approach to understand how cells decode multiple cues to make decisions.
KW - cellular signal processing machinery
KW - directed cell migration
KW - systems biology
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M3 - Conference contribution
AN - SCOPUS:85175713376
T3 - MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences
SP - 356
EP - 357
BT - MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PB - Chemical and Biological Microsystems Society
T2 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2022
Y2 - 23 October 2022 through 27 October 2022
ER -