Cell–cell adhesion interface: orthogonal and parallel forces from contraction, protrusion, and retraction[version 1; peer review: 2 approved]

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Abstract

The epithelial lateral membrane plays a central role in the integration of intercellular signals and, by doing so, is a principal determinant in the emerging properties of epithelial tissues. Mechanical force, when applied to the lateral cell–cell interface, can modulate the strength of adhesion and influence intercellular dynamics. Yet the relationship between mechanical force and epithelial cell behavior is complex and not completely understood. This commentary aims to provide an investigative look at the usage of cellular forces at the epithelial cell–cell adhesion interface.

Original languageEnglish (US)
Article number1544
JournalF1000Research
Volume7
DOIs
StatePublished - 2018

Keywords

  • Actin
  • Adhesion
  • Cell-cell
  • Contraction
  • Epithelial
  • Force
  • Intercellular
  • Lateral membrane
  • Protrusion
  • Retraction

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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