Cell Size-Based Decision-Making of a Viral Gene Circuit

Kathrin Bohn-Wippert, Erin N. Tevonian, Yiyang Lu, Meng Yao Huang, Melina R. Megaridis, Roy D. Dar

Research output: Contribution to journalArticle

Abstract

Bohn-Wippert et al. investigate reactivation of T cells latently infected with HIV. They discover that only larger cells exit latency, while smaller cells remain silent. Viral expression bursts are cell size and cell-cycle dependent, presenting dynamic cell states, capable of active control, as sources of viral fate determination.

Original languageEnglish (US)
Pages (from-to)3844-3857.e5
JournalCell Reports
Volume25
Issue number13
DOIs
StatePublished - Dec 26 2018

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Bohn-Wippert, K., Tevonian, E. N., Lu, Y., Huang, M. Y., Megaridis, M. R., & Dar, R. D. (2018). Cell Size-Based Decision-Making of a Viral Gene Circuit. Cell Reports, 25(13), 3844-3857.e5. https://doi.org/10.1016/j.celrep.2018.12.009