Cell Size-Based Decision-Making of a Viral Gene Circuit

Kathrin Bohn-Wippert, Erin N. Tevonian, Yiyang Lu, Meng Yao Huang, Melina R. Megaridis, Roy David Dar

Research output: Contribution to journalArticle

Abstract

Bohn-Wippert et al. investigate reactivation of T cells latently infected with HIV. They discover that only larger cells exit latency, while smaller cells remain silent. Viral expression bursts are cell size and cell-cycle dependent, presenting dynamic cell states, capable of active control, as sources of viral fate determination.

Original languageEnglish (US)
Pages (from-to)3844-3857.e5
JournalCell Reports
Volume25
Issue number13
DOIs
StatePublished - Dec 26 2018

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T-cells
Viral Genes
Gene Regulatory Networks
Cell Size
Decision Making
Genes
Decision making
Cells
Networks (circuits)
Cell Cycle
HIV
T-Lymphocytes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Bohn-Wippert, K., Tevonian, E. N., Lu, Y., Huang, M. Y., Megaridis, M. R., & Dar, R. D. (2018). Cell Size-Based Decision-Making of a Viral Gene Circuit. Cell Reports, 25(13), 3844-3857.e5. https://doi.org/10.1016/j.celrep.2018.12.009

Cell Size-Based Decision-Making of a Viral Gene Circuit. / Bohn-Wippert, Kathrin; Tevonian, Erin N.; Lu, Yiyang; Huang, Meng Yao; Megaridis, Melina R.; Dar, Roy David.

In: Cell Reports, Vol. 25, No. 13, 26.12.2018, p. 3844-3857.e5.

Research output: Contribution to journalArticle

Bohn-Wippert, K, Tevonian, EN, Lu, Y, Huang, MY, Megaridis, MR & Dar, RD 2018, 'Cell Size-Based Decision-Making of a Viral Gene Circuit', Cell Reports, vol. 25, no. 13, pp. 3844-3857.e5. https://doi.org/10.1016/j.celrep.2018.12.009
Bohn-Wippert K, Tevonian EN, Lu Y, Huang MY, Megaridis MR, Dar RD. Cell Size-Based Decision-Making of a Viral Gene Circuit. Cell Reports. 2018 Dec 26;25(13):3844-3857.e5. https://doi.org/10.1016/j.celrep.2018.12.009
Bohn-Wippert, Kathrin ; Tevonian, Erin N. ; Lu, Yiyang ; Huang, Meng Yao ; Megaridis, Melina R. ; Dar, Roy David. / Cell Size-Based Decision-Making of a Viral Gene Circuit. In: Cell Reports. 2018 ; Vol. 25, No. 13. pp. 3844-3857.e5.
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