Cell signaling pathways in vertebrate lens regeneration

Jonathan J. Henry, Alvin G. Thomas, Paul W. Hamilton, Lisa Moore, Kimberly J. Perry

Research output: Chapter in Book/Report/Conference proceedingChapter


Certain vertebrates are capable of regenerating parts of the eye, including the lens. Depending on the species, two principal forms of in vivo lens regeneration have been described wherein the new lens arises from either the pigmented epithelium of the dorsal iris or the cornea epithelium. These forms of lens regeneration are triggered by retinal factors present in the eye. Studies have begun to illuminate the nature of the signals that support lens regeneration. This review describes evidence for the involvement of specific signaling pathways in lens regeneration, including the FGF, retinoic acid, TGF-beta, Wnt, and Hedgehog pathways.

Original languageEnglish (US)
Title of host publicationNew Perspectives in Regeneration
Number of pages24
StatePublished - 2013

Publication series

NameCurrent Topics in Microbiology and Immunology
ISSN (Print)0070-217X

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology
  • Immunology
  • Microbiology (medical)


Dive into the research topics of 'Cell signaling pathways in vertebrate lens regeneration'. Together they form a unique fingerprint.

Cite this