Cell renewal in adjoining intestinal and tracheal epithelia of Manduca

James B. Nardi, Charles Mark Bee, Lou Ann Miller, Divya Mathur, Benjamin Ohlstein

Research output: Contribution to journalArticle

Abstract

Cell renewal continuously replaces dead or dying cells in organs such as human and insect intestinal (midgut) epithelia; in insects, control of self-renewal determines insects' responses to any of the myriad pathogens and parasites of medical and agricultural importance that enter and cross their midgut epithelia. Regenerative cells occur in the midgut epithelia of many, if not all, insects and are probably derived from a distinctive population of stem cells. The control of proliferation and differentiation of these midgut regenerative cells is assumed to be regulated by an environment of adjacent cells that is referred to as a regenerative cell niche. An antibody to fasciclin II marks cell surfaces of tracheal regenerative cells associated with rapidly growing midgut epithelia. Tracheal regenerative cells and their neighboring midgut regenerative cells proliferate and differentiate in concert during the coordinated growth of the midgut and its associated muscles, nerves and tracheal cells.

Original languageEnglish (US)
Pages (from-to)487-493
Number of pages7
JournalJournal of insect physiology
Volume57
Issue number4
DOIs
StatePublished - Apr 1 2011

Keywords

  • Fasciclin II
  • Intestinal cells
  • Midgut
  • Regenerative cells
  • Stem cells
  • Tracheae

ASJC Scopus subject areas

  • Physiology
  • Insect Science

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