Abstract

A hydrogel biochip combining microfluidic mixing and orthogonal supplementation strategies is developed and validated to allow facile generation of libraries of optically transparent 3D culture microenvironments. Live, on-chip tracing of embryonic stem cell differentiation and endothelial cell tubulogenesis confirms that the platform can be used to both create communities of discrete 3D microenvironments as well as to locally monitor subsequent divergent responses at both single cell and multi-cell scales.

Original languageEnglish (US)
Pages (from-to)3076-3081
Number of pages6
JournalSmall
Volume9
Issue number18
DOIs
StatePublished - Sep 23 2013

Keywords

  • biomaterials
  • microfluidics
  • stem cells
  • tissue engineering
  • tubulogenesis

ASJC Scopus subject areas

  • Biomaterials
  • Engineering (miscellaneous)
  • Biotechnology
  • Medicine(all)

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