Abstract

A cell-mimetic object is described which consists of a pH-responsive μgel modified with a lipid membrane coating. Due to the cell-like nature of the object, it will be referred to as a "cell-gel". It is created by the covalent attachment of fatty acids to the surface of a microgel within a microfluidic system, forming the inner monolayer. This hydrophobic surface acts as a template for the self-assembly of the second leaflet, which spontaneously forms when the structure is exposed to phospholipid solutions. Since the lipid layer is impermeable to ions, a different pH can be maintained within the hydrogel, allowing it to remain contracted while bathed in a pH that would normally cause expansion in an unmodified hydrogel. Ultimately, biological molecules, such as receptors, will be incorporated into the bilayer. Interactions with these components can cause membrane disruption, leading to the expansion of the hydrogel from the passage of ions through the lipid layer. With further development, this object can serve as a biosensor.

Original languageEnglish (US)
Title of host publication1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology - Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages340-344
Number of pages5
ISBN (Electronic)0780366034, 9780780366039
DOIs
StatePublished - 2000
Event1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology, MMB 2000 - Lyon, France
Duration: Oct 12 2000Oct 14 2000

Other

Other1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology, MMB 2000
CountryFrance
CityLyon
Period10/12/0010/14/00

ASJC Scopus subject areas

  • Engineering(all)

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