Cell cycle control

Thomas W. Jacobs

Research output: Contribution to journalArticle

Abstract

Cell division in plants serves to subdivide space in the expanding organism rather than to supply cellular building blocks, as it does in animals. Despite these contrasting developmental contexts, transitions through and between stages of the mitotic cell cycle are controlled in both kingdoms by related families of cyclin-dependent kinases (CDKs) and their regulatory subunits (cyclins). Passage of animal cells through the G1 and S phases of the cycle is controlled by complexes of CDKs, cyclins, transcription factors, tumor supressor proteins, and inhibitor proteins. None of these complexes has been identified in plants. Most plant cell cycle regulators characterized to date resemble those active in the G2-M transition in yeast and animal cells, although biochemical demonstrations of their roles in plants are lacking. Also awaiting elucidation in plant systems are the essential connections between CDK-cyclin activities and hormonal or developmental signals.

Original languageEnglish (US)
Pages (from-to)317-339
Number of pages23
JournalAnnual Review of Plant Physiology and Plant Molecular Biology
Volume46
Issue number1
DOIs
StatePublished - Jan 1 1995

Keywords

  • Cell division
  • Cyclin
  • Cyclin-dependent kinase
  • Mitosis
  • Protein kinase

ASJC Scopus subject areas

  • Medicine(all)

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