Abstract
The epithelial lateral membrane plays a central role in the integration of intercellular signals and, by doing so, is a principal determinant in the emerging properties of epithelial tissues. Mechanical force, when applied to the lateral cell-cell interface, can modulate the strength of adhesion and influence intercellular dynamics. Yet the relationship between mechanical force and epithelial cell behavior is complex and not completely understood. This commentary aims to provide an investigative look at the usage of cellular forces at the epithelial cell-cell adhesion interface.
Original language | English (US) |
---|---|
Journal | F1000Research |
Volume | 7 |
DOIs | |
State | Published - Jan 1 2018 |
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Keywords
- actin
- adhesion
- cell-cell
- contraction
- epithelial
- force
- intercellular
- lateral membrane
- protrusion
- retraction
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Immunology and Microbiology(all)
- Pharmacology, Toxicology and Pharmaceutics(all)
Cite this
Cell-cell adhesion interface : orthogonal and parallel forces from contraction, protrusion, and retraction. / Tang, Vivian W.
In: F1000Research, Vol. 7, 01.01.2018.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Cell-cell adhesion interface
T2 - orthogonal and parallel forces from contraction, protrusion, and retraction
AU - Tang, Vivian W.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - The epithelial lateral membrane plays a central role in the integration of intercellular signals and, by doing so, is a principal determinant in the emerging properties of epithelial tissues. Mechanical force, when applied to the lateral cell-cell interface, can modulate the strength of adhesion and influence intercellular dynamics. Yet the relationship between mechanical force and epithelial cell behavior is complex and not completely understood. This commentary aims to provide an investigative look at the usage of cellular forces at the epithelial cell-cell adhesion interface.
AB - The epithelial lateral membrane plays a central role in the integration of intercellular signals and, by doing so, is a principal determinant in the emerging properties of epithelial tissues. Mechanical force, when applied to the lateral cell-cell interface, can modulate the strength of adhesion and influence intercellular dynamics. Yet the relationship between mechanical force and epithelial cell behavior is complex and not completely understood. This commentary aims to provide an investigative look at the usage of cellular forces at the epithelial cell-cell adhesion interface.
KW - actin
KW - adhesion
KW - cell-cell
KW - contraction
KW - epithelial
KW - force
KW - intercellular
KW - lateral membrane
KW - protrusion
KW - retraction
UR - http://www.scopus.com/inward/record.url?scp=85055075708&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85055075708&partnerID=8YFLogxK
U2 - 10.12688/f1000research.15860.1
DO - 10.12688/f1000research.15860.1
M3 - Review article
C2 - 30345009
AN - SCOPUS:85055075708
VL - 7
JO - F1000Research
JF - F1000Research
SN - 2046-1402
ER -