Cell and tissue engineering for liver disease

Sangeeta N. Bhatia; Gregory H. Underhill; Kenneth S. Zaret; Ira J. Fox

doi:10.1126/scitranslmed.3005975

Cell and tissue engineering for liver disease

Sangeeta N. Bhatia, Gregory H. Underhill, Kenneth S. Zaret, Ira J. Fox

Research output: Contribution to journal › Review article › peer-review

Abstract

Despite the tremendous hurdles presented by the complexity of the liver's structure and function, advances in liver physiology, stem cell biology and reprogramming, and the engineering of tissues and devices are accelerating the development of cell-based therapies for treating liver disease and liver failure. This State of the Art Review discusses both the near- and long-term prospects for such cell-based therapies and the unique challenges for clinical translation.

Original language	English (US)
Article number	245sr2
Journal	Science Translational Medicine
Volume	6
Issue number	245
DOIs	https://doi.org/10.1126/scitranslmed.3005975
State	Published - Jul 16 2014

ASJC Scopus subject areas

Medicine(all)

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10.1126/scitranslmed.3005975

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title = "Cell and tissue engineering for liver disease",

abstract = "Despite the tremendous hurdles presented by the complexity of the liver's structure and function, advances in liver physiology, stem cell biology and reprogramming, and the engineering of tissues and devices are accelerating the development of cell-based therapies for treating liver disease and liver failure. This State of the Art Review discusses both the near- and long-term prospects for such cell-based therapies and the unique challenges for clinical translation.",

author = "Bhatia, {Sangeeta N.} and Underhill, {Gregory H.} and Zaret, {Kenneth S.} and Fox, {Ira J.}",

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AU - Bhatia, Sangeeta N.

AU - Underhill, Gregory H.

AU - Zaret, Kenneth S.

AU - Fox, Ira J.

PY - 2014/7/16

Y1 - 2014/7/16

N2 - Despite the tremendous hurdles presented by the complexity of the liver's structure and function, advances in liver physiology, stem cell biology and reprogramming, and the engineering of tissues and devices are accelerating the development of cell-based therapies for treating liver disease and liver failure. This State of the Art Review discusses both the near- and long-term prospects for such cell-based therapies and the unique challenges for clinical translation.

AB - Despite the tremendous hurdles presented by the complexity of the liver's structure and function, advances in liver physiology, stem cell biology and reprogramming, and the engineering of tissues and devices are accelerating the development of cell-based therapies for treating liver disease and liver failure. This State of the Art Review discusses both the near- and long-term prospects for such cell-based therapies and the unique challenges for clinical translation.

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Cell and tissue engineering for liver disease

Abstract

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