Catalytic, nucleophilic allylation of aldehydes with allyl acetate

Scott E. Denmark, Son T. Nguyen

Research output: Contribution to journalArticle

Abstract

(Chemical Equation Presented) A new catalytic allylation of aldehydes has been developed that employs allyl acetate as the allylating reagent. Under catalysis by ruthenium trichloride (3 mol %) in the presence of carbon monoxide (30 psi), water (1.5 equiv), and Methylamine (0.1 equiv), a wide range of aromatic, olefinic, and aliphatic aldehydes are efficiently allylated under mild conditions (70 °C, 24-48 h). The stoichiometric byproducts of this reaction are carbon dioxide and acetic acid.

Original languageEnglish (US)
Pages (from-to)781-784
Number of pages4
JournalOrganic Letters
Volume11
Issue number3
DOIs
StatePublished - Feb 5 2009

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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