Catalyst-controlled aliphatic C—H oxidations

M Christina White (Inventor), Paul E Gormisky (Inventor)

Research output: Patent

Abstract

The invention provides simple small molecule, non-heme iron catalyst systems with broad substrate scope that can predictably enhance or overturn a substrate's inherent reactivity preference for sp3-hybridized C—H bond oxidation. The invention also provides methods for selective aliphatic C—H bond oxidation. Furthermore, a structure-based catalyst reactivity model is disclosed that quantitatively correlates the innate physical properties of the substrate to the site-selectivities observed as a function of the catalyst. The catalyst systems can be used in combination with oxidants such as hydrogen peroxide to effect highly selective oxidations of unactivated sp3 C—H bonds over a broad range of substrates.
Original languageEnglish (US)
U.S. patent number9925528
Filing date9/9/14
StatePublished - Mar 27 2018

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